Alpha-V Integrin Targeted PET Imagining of Breast Cancer Angiogenesis and Lose-Dose Metronomic Anti-Angiogenic Chemotherapy Efficacy

Alpha-V Integrin Targeted PET Imagining of Breast Cancer Angiogenesis and Lose-Dose Metronomic Anti-Angiogenic Chemotherapy Efficacy
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Total Pages: 94
Release: 2005
Genre:
ISBN:
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The overall objective of this project is to develop I 18F-labeled RGD peptide derivatives for breast cancer imaging with prolonged tumor retention and improved in vivo kinetics to visualize and quantify av-integrin expression and subsequently evaluate the metronomic anti angiogenic chemotherapy efficacy on tumor regression, necrosis, and angiogenesis. Specific Aims: (1) To optimize 18F-labeled RGD peptide tracer for breast cancer imaging with prolonged tumor retention and improved in vivo kinetics. (2) To demonstrate the feasibility of PET/18F-RGD to image breast tumor growth, spread, and angiogenesis as well as quantifying av-integrin expression level during breast tumor neovascularization overtime. (3) To evaluate the efficacy of EMD 121974/paclitaxel combination on tumor regression, necrosis, and angiogenesis and demonstrate the feasibility of PET/18F-RGD to monitor the treatment outcomes. Major findings: We have developed a dimeric RGD peptide tracer [18F]FRGD2 that has high integrin av beta 3 binding affinity and favorable in vivo kinetics. Furthermore, the binding potential calculated from simplified tracer kinetic modeling such as Logan plot appears to be an excellent indicator of tumor integrin density. We have also evaluated the antitumor activity of paclitaxel (PTX) conjugated with a bicyclic peptide E[c(RGDyK)]2 (RGD) in a metastatic breast cancer cell line (MDA-MB-435). Our results demonstrate the potential of tumor-targeted delivery of paclitaxel based on the specific recognition of cell adhesion molecule av beta 3 integrin to reduce toxicity and enhance selective killing of cancer cells.

Alpha-v Integrin Targeted PET Imaging of Breast Cancer Angiogenesis and Low-Dose Metronomic Anti-Angiogenic Chemotherapy Efficacy

Alpha-v Integrin Targeted PET Imaging of Breast Cancer Angiogenesis and Low-Dose Metronomic Anti-Angiogenic Chemotherapy Efficacy
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Publisher:
Total Pages: 16
Release: 2006
Genre:
ISBN:
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The overall objective of this project is to develop 18F-labeled RGD peptide derivatives for breast cancer imaging with prolonged tumor retention and improved in vivo kinetics to visualize and quantify alpha-v integrin expression and subsequently evaluate the metronomic anti-angiogenic chemotherapy efficacy on tumor regression necrosis and angiogenesis. Specific Aims: (1) To optimize 18F-labeled RGD peptide tracer for breast cancer imaging with prolonged tumor retention and improved in vivo kinetics. (2) To demonstrate the feasibility of PET/18F-RGD to image breast tumor growth spread and angiogenesis as well as quantifying alpha-v integrin expression level during breast tumor neovascularization over time. (3) To evaluate the efficacy of EMD 121974/paclitaxel combination on tumor regression necrosis and angiogenesis and demonstrate the feasibility of PET/18F-RGD to monitor the treatment outcomes. Major findings: We have previously reported that 18F-FB-E[c(RGDyK)]2 (18F-FRGD2) allows quantitative PET imaging of integrin alpha-v beta-3 expression. However the potential clinical translation was hampered by the relatively low radiochemical yield. We thus developed a new tracer 8F-FB-mini-PEG-E[c(RGDyK)]2 (18F-FPRGD2) that has improved radiolabeling yield without compromising the tumor targeting efficiency and in vivo kinetics. We also showed that RGD-Pacitaxel treatment cause significant reduction in tumor growth in integrin positive MDA-MB-435 breast cancer model which is superior to the combination of RGD and paclitaxel.

Metronomic Chemotherapy

Metronomic Chemotherapy
Author: Guido Bocci
Publisher: Springer
Total Pages: 302
Release: 2014-09-04
Genre: Medical
ISBN: 3662436043
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This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Withrow and MacEwen's Small Animal Clinical Oncology

Withrow and MacEwen's Small Animal Clinical Oncology
Author: Stephen J. Withrow
Publisher: Elsevier Health Sciences
Total Pages: 863
Release: 2007-01-01
Genre: Medical
ISBN: 0721605583
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Focusing on cancer in dogs and cats, this extensively updated 4th edition provides comprehensive coverage of the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. Ideal for students, practitioners, and those involved in academic research, this book's full-color images and user-friendly format provide quick and easy access to today's most important information on cancer in the small animal patient. Full-color format throughout and full-color illustrations make information more accessible and provide accurate representations of clinical appearance.Chapters are clustered into four major sections: The Biology and Pathogenesis of Cancer, Diagnostic Procedures for the Cancer Patient, Therapeutic Modalities for the Cancer Patient, and Specific Malignancies in the Small Animal Patient.The consistent format includes incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies in the small animal cancer patient.Features cutting edge information on the complications of cancer, pain management, and the latest treatment modalities. The latest information on the etiology of cancer, including genetic, chemical, physical, and hormonal factors, as well as cancer-causing viruses.Coverage of molecular-targeted therapy of cancer, plus new and emerging therapeutic techniques.New information on molecular diagnostic procedures for the cancer patient.The latest diagnostic imaging techniques in clinical oncology.Discussions of compassion and supportive care, from chronic pain management and nutrition to end-of-life issues and grief support.

Tumor Vascularization

Tumor Vascularization
Author: Domenico Ribatti
Publisher: Academic Press
Total Pages: 198
Release: 2020-01-21
Genre: Science
ISBN: 0128194944
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Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment

Brain Tumor Imaging

Brain Tumor Imaging
Author: Elke Hattingen
Publisher: Springer
Total Pages: 166
Release: 2015-09-02
Genre: Medical
ISBN: 3642450407
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This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.

Multimodal Concepts for Integration of Cytotoxic Drugs

Multimodal Concepts for Integration of Cytotoxic Drugs
Author: Martin J. Brown
Publisher: Springer Science & Business Media
Total Pages: 346
Release: 2006-08-06
Genre: Medical
ISBN: 3540356622
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The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented.

Targeted Drug Delivery : Concepts and Design

Targeted Drug Delivery : Concepts and Design
Author: Padma V. Devarajan
Publisher: Springer
Total Pages: 788
Release: 2014-12-08
Genre: Medical
ISBN: 3319113550
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This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Tumour Angiogenesis

Tumour Angiogenesis
Author: R. John Bicknell
Publisher:
Total Pages: 416
Release: 1997
Genre: Neovascularization
ISBN:
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Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases,extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforminggrowth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and thetherapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.

Radiation Oncology Advances

Radiation Oncology Advances
Author: Søren M. Bentzen
Publisher: Springer Science & Business Media
Total Pages: 347
Release: 2007-09-20
Genre: Medical
ISBN: 0387367446
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This book provides an up-to-date comprehensive overview of the exciting new developments shaping the current and future practice of radiation oncology. Advances in treatment planning and delivery, in biological targeted therapies combined with radiation and in functional and molecular imaging are all covered in a single volume. All of these advances are discussed by leading experts in the field and with a critical evaluation of their clinical relevance throughout.