Advancements of Mass Spectrometry in Biomedical Research

Advancements of Mass Spectrometry in Biomedical Research
Author: Alisa G. Woods
Publisher: Springer
Total Pages: 813
Release: 2019-07-25
Genre: Science
ISBN: 3030159507

Download Advancements of Mass Spectrometry in Biomedical Research Book in PDF, Epub and Kindle

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field.

Medical Applications of Mass Spectrometry

Medical Applications of Mass Spectrometry
Author: Karoly Vekey
Publisher: Elsevier
Total Pages: 607
Release: 2011-08-11
Genre: Science
ISBN: 0080554652

Download Medical Applications of Mass Spectrometry Book in PDF, Epub and Kindle

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry.* Guides the reader from basic principles and methods to cutting edge applications.* There is NO comparable book on the market to fill this fast growing field.

Advancements of Mass Spectrometry in Biomedical Research

Advancements of Mass Spectrometry in Biomedical Research
Author: Alisa G. Woods
Publisher: Springer
Total Pages: 0
Release: 2016-09-24
Genre: Science
ISBN: 9783319378923

Download Advancements of Mass Spectrometry in Biomedical Research Book in PDF, Epub and Kindle

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine.

Mass Spectrometry in Biology & Medicine

Mass Spectrometry in Biology & Medicine
Author: A.L. Burlingame
Publisher: Springer Science & Business Media
Total Pages: 576
Release: 1999-09-14
Genre: Science
ISBN: 159259719X

Download Mass Spectrometry in Biology & Medicine Book in PDF, Epub and Kindle

Leading practitioners detail revolutionary new spectrometric techniques for the identification and covalent structural characterization of macromolecules, proteins, glycoconjugates, and nucleic acids. Based on the Fourth International Symposium on Mass Spectrometry in the Health and Life Sciences held in San Francisco in 1998, this invaluable book contains tested strategies for solving many significant biomedical research problems. The techniques use mass spectrometry, automated computer processing of spectral information, and gene, protein, and EST databases for genomic and proteomic correlations. Mass Spectrometry in Biology and Medicine offers a unique opportunity to explore and apply these new techniques of mass spectrometry that are revolutionizing the identification and structural characterization of proteins, carbohydrates, and nucleic acids.

Mass Spectrometry of Proteins and Peptides

Mass Spectrometry of Proteins and Peptides
Author: Mary S. Lipton
Publisher: Humana Press
Total Pages: 0
Release: 2014-11-27
Genre: Science
ISBN: 9781627037969

Download Mass Spectrometry of Proteins and Peptides Book in PDF, Epub and Kindle

When the last edition of this book was published in 2000, the field of proteomics was in its infancy. At that time, multidimensional liquid chromatographic separations were being introduced as an alternative to traditional gel-based techniques for separating complex protein and peptide mixtures prior to mass spectrometric detection. Today, this approach – referred to as shotgun proteomics – is considered routine for lar- scale global analyses of protein mixtures. Now in its adolescence, proteomics is fundamentally transforming biological and medical research. Much of this transformation can be attributed to technological advancements, particularly in mass spectrometry. Much wider accessibility of hi- resolution and mass measurement accuracy instrumentation in recent years has ini- ated a new revolution in the field by providing more reliable data and shifting the focus from cataloging proteins to precisely quantifying changes in protein abundance over time and in response to stimuli. Advanced mass spectrometers and novel ion d- sociation schemes such as electron transfer/capture dissociation make it possible to venture boldly into the maze of protein posttranslational modifications, which are an integral component of understanding functional proteomics in the spatial and t- poral domains. Another area that has benefited from these advancements is top-down proteomics, an emerging method essential for characterizing various protein variants that has potentially high impact in biomedical research.

Sample Preparation in Biological Mass Spectrometry

Sample Preparation in Biological Mass Spectrometry
Author: Alexander R. Ivanov
Publisher: Springer Science & Business Media
Total Pages: 1081
Release: 2011-06-15
Genre: Science
ISBN: 9400708289

Download Sample Preparation in Biological Mass Spectrometry Book in PDF, Epub and Kindle

The aim of this book is to provide the researcher with important sample preparation strategies in a wide variety of analyte molecules, specimens, methods, and biological applications requiring mass spectrometric analysis as a detection end-point. In this volume we have compiled the contributions from several laboratories which are employing mass spectrometry for biological analysis. With the latest inventions and introduction of highly sophisticated mass spectrometry equipment sample preparation becomes an extremely important bottleneck of biomedical analysis. We have a goal of giving the reader several successful examples of sample preparation, development and optimization, leading to the success in analytical steps and proper conclusions made at the end of the day. This book is structured as a compilation of contributed chapters ranging from protocols to research articles and reviews. The main philosophy of this volume is that sample preparation methods have to be optimized and validated for every project, for every sample type and for every downstream analytical technique.

Advances in Mass Spectrometry, Volume 12

Advances in Mass Spectrometry, Volume 12
Author: P.G. Kistemaker
Publisher: Elsevier
Total Pages: 975
Release: 2012-12-02
Genre: Science
ISBN: 0444599452

Download Advances in Mass Spectrometry, Volume 12 Book in PDF, Epub and Kindle

These proceedings, containing the texts of the invited lectures, cover all aspects of mass spectrometry including theory, fundamental studies, applications and instrumentation. Emphasis is placed on recent developments. A complete listing of the posters is included.

Mass Spectrometry

Mass Spectrometry
Author: Dominic M. Desiderio
Publisher: Springer Science & Business Media
Total Pages: 360
Release: 2013-11-11
Genre: Science
ISBN: 1489911731

Download Mass Spectrometry Book in PDF, Epub and Kindle

In response to the growing use of mass spectrometry in the clinical and biomedical fields, this book collects recent research involving electrospray ionization, neuronal systems, and structural modifications of proteins. The significant advances in instrumentation, methodology, experimentation presented herein will serve to expand the current concept of clinical mass spectrometry.