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| Author | : Ersin Sayar |
| Publisher | : |
| Total Pages | : 502 |
| Release | : 2013 |
| Genre | : Mechanical engineering |
| ISBN | : |
Advisor: Bakhtier Farouk.
| Author | : |
| Publisher | : |
| Total Pages | : 7 |
| Release | : 2008 |
| Genre | : Nanofluids |
| ISBN | : |
| Author | : Suman Chakraborty |
| Publisher | : CRC Press |
| Total Pages | : 368 |
| Release | : 2012-10-04 |
| Genre | : Science |
| ISBN | : 143989924X |
The advancements in micro- and nano-fabrication techniques, especially in the last couple of decades, have led research communities, over the world, to invest unprecedented levels of attention on the science and technology of micro- and nano-scale devices and the concerned applications. With an intense focus on micro- and nanotechnology from a fluidic perspective, Microfluidics and Microscale Transport Processes provides a broad review of advances in this field. A comprehensive compendium of key indicators to recent developments in some very active research topics in microscale transport processes, it supplies an optimal balance between discussions of concrete applications and development of fundamental understanding. The chapters discuss a wide range of issues in the sub-domains of capillary transport, fluidic resistance, electrokinetics, substrate modification, rotational microfluidics, and the applications of the phenomena of these sub-domains in diverse situations ranging from non-biological to biological ones like DNA hybridization and cellular biomicrofluidics. The book also addresses a generic problem of particle transport in nanoscale colloidal suspensions and includes a chapter on Lattice-Boltzmann methods for phase-changing problems which represents a generic particle based approach that may be useful to address many microfluidic problems of interdisciplinary relevance.
| Author | : |
| Publisher | : |
| Total Pages | : |
| Release | : 2004 |
| Genre | : |
| ISBN | : |
We have demonstrated a non-contact method of concentrating and mixing particles in a plastic microfluidic chamber employing acoustic radiation pressure. A flaw cell package has also been designed that integrates liquid sample interconnects, electrical contacts and a removable sample chamber. Experiments were performed on 1, 3, 6, and 10[micro]m polystyrene beads. Increased antibody binding to a solid-phase substrate was observed in the presence of acoustic mixing due to improve mass transport.
| Author | : Hsueh-Chia Chang |
| Publisher | : Cambridge University Press |
| Total Pages | : 526 |
| Release | : 2009-11-09 |
| Genre | : Technology & Engineering |
| ISBN | : 9780521860253 |
Electrokinetics is currently the mechanism of choice for fluid actuation and bioparticle manipulation at microscale and nanoscale dimensions. There has recently been widespread interest in the use of AC electric fields, given the many advantages it offers over DC electrokinetics. Nevertheless, a fundamental understanding of the governing mechanisms underlying the complex and nonlinear physicochemical hydrodynamics associated with these systems is required before practical microfluidic and nanofluidic devices can be engineered. This text aims to provide a comprehensive treatise on both classical equilibrium electrokinetic phenomena as well as the more recent non-equilibrium phenomena associated with both DC and AC electrokinetics in the context of their application to the design of microfluidic and nanofluidic technology. In particular, Leslie Yeo and Hsueh-Chia Chang discuss the linear and nonlinear theories underlying electroosmosis, electrophoresis, and dielectrophoresis pertaining to electrolytes as well as dielectric systems. Interfacial electrokinetic phenomena such as electrospraying, electrospinning, and electrowetting are also discussed.
| Author | : Liqing Ren |
| Publisher | : National Library of Canada = Bibliothèque nationale du Canada |
| Total Pages | : |
| Release | : 2004 |
| Genre | : |
| ISBN | : 9780612917774 |
Both experimental and numerical studies about the transport phenomena in microfluidic devices are presented in this thesis. The transport phenomena of interest are pressure driven flow and electroosmotic driven flow with a Reynolds number on the order of unit, and the associated mass transport phenomena. The studied microfluidic devices include fused silicon capillaries, in-house made glass microchannels and a glass chip with a crossing-linked microchannel etched into its surface. The hydraulic diameter ranges from 20 mum to 200 mum. The on-chip sample injection processes are studied both experimentally and numerically. Fluorescent dyes are employed here as the sample and the sample injection (loading and dispensing) processes on a microfluidic chip are visualized using an in-house developed laser visualization system and techniques. The experimentally measured sample injection process is compared with the numerical simulation results. Reasonable agreements were found between the model predictions and experimental measurements. The model is further developed in order to improve the simulation accuracy and save significant computation time as compared with the previous model. A general model capable of simulating general on-chip injection processes is finally developed to make the numerical analysis tools complete. This general model considers the electrical conductivity difference present at microfluidic applications, which is not considered normally due to its complexity. The electroosomotic flow is commonly applied in microfluidic devices as a pump, therefore, the flow rate determination is of particular interest. An experimental setup and corresponding data acquisition system are developed to measure electroosmotic flow rate by employing solution displacement process and current monitoring technique. A theoretical model is developed to improve the accuracy of this technique. A numerical model is developed to simulate this displacing process and to obtain flow rate. Good agreements between numerical simulations and experimental measurements verified the developed model. The electrokinetic transport phenomena of pressure driven flow in microchannels are studied based on a simultaneous solution to the developed pressure driven flow model. It is found that the flow characteristics of microchannels differ significantly from that in macrosized devices showing high viscous effects. The numerical results are compared with the experimental measurements and good agreement verified the developed model.
| Author | : Xiangchun Xuan |
| Publisher | : |
| Total Pages | : 386 |
| Release | : 2006 |
| Genre | : |
| ISBN | : 9780494219652 |
This thesis studies the electrokinetic transport phenomena in microfluidic devices. The scope of this thesis work is best broken down into two parts. The first part concentrates on the theoretical and experimental study of Joule heating effects on the transports of heat, electricity, momentum and mass species in capillary-based electrophoretic separations. It is found that Joule heating effects cause temperature gradients in both cross-stream and stream-wise directions. As a result, the electric field and thus the electrical body become non-uniform in flow equations so that pressure gradients are induced passively to satisfy the mass continuity. This disturbance to the otherwise plug-like electroosmotic flow field increases the sample dispersion and hence reduces the separation efficiency. The second part of this thesis work concerns the electrophoretic motion and the electrokinetic manipulation (for example, focusing, dispensing and separation) of particles and cells in microfluidic chips. Theoretical predictions of the particle electrophoretic mobility that are available in the literature are experimentally validated in both cylindrical and rectangular microchannels by visualizing the single particle motion. We also examine intensively the accelerated particle electrophoretic motion and separation in converging-diverging microchannels along with the focused electrophoretic motion of particles and cells in cross-microchannels. In addition, an electrokinetic method is proposed to dispense efficiently single particles in a double-cross microchannel. The totally electrokinetic manipulation of particles is believed to facilitate developing integrated lab-on-a-chip devices for studies of single cells.
| Author | : Mehmet Basar Karacor |
| Publisher | : |
| Total Pages | : 81 |
| Release | : 2009 |
| Genre | : Electrokinetics |
| ISBN | : |
Electroosmotic flow control in microfluidic devices is an important and challenging problem, as electroosmosis directly influences separation efficiencies in lab-on-chip applications. In this study, a non-mechanical passive flow directing method is presented for electrokinetically driven flow. Due to the high surface-area-to-volume (SA/V) ratio, surface properties dominate the flow in microfluidic channels. For electrokinetically driven flows, the main surface property affecting electroosmotic flows is the surface [zeta] potential, which is related to the effective surface charge density. By changing the effective surface charge density, the electroosmotic flow rates of charged species can be controlled in microfluidic channels. In this work, to change the effective surface charge density, surfaces were chemically modified with --Br, --NH2 and --CH3 functional groups by "click" chemistry. Since these functional surface layers are integrated within model glass microfluidic devices prepared by standard microfabrication procedures, the first step was to investigate the stability of the adherent surface layers to a variety of microfabrication conditions. A model "Y" shaped glass microfluidic device was developed. One leg of this model microfluidic device was selectively chemically modified to alter the [zeta] potential and thereby increase or decrease the electroosmotic flow with respect to rest of the device. Electroosmotic flow is visualized by using marker dyes under a fluorescent microscope. In addition, experiments were validated by using the CFD code in COMSOL. The experiments concluded that the surface layers are stable to a variety of conditions including a wide pH range (pH 3 -- pH 11), solvent exposure, acid and base exposure, and UV light. Extreme conditions such as a piranha solution or oxidative plasma degrade the surface layers. Electrokinetic flow experiments show that depending on the charge of a species the electroosmotic flow is preferentially directed as a function of the [zeta] potential in the microfluidic channels.
| Author | : Dongqing Li |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 2242 |
| Release | : 2008-08-06 |
| Genre | : Technology & Engineering |
| ISBN | : 0387324682 |
Covering all aspects of transport phenomena on the nano- and micro-scale, this encyclopedia features over 750 entries in three alphabetically-arranged volumes including the most up-to-date research, insights, and applied techniques across all areas. Coverage includes electrical double-layers, optofluidics, DNC lab-on-a-chip, nanosensors, and more.
| Author | : Xiujun (James) Li |
| Publisher | : Elsevier |
| Total Pages | : 689 |
| Release | : 2013-10-31 |
| Genre | : Science |
| ISBN | : 0857097040 |
Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications. The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering
