A History of Transplantation Immunology

A History of Transplantation Immunology
Author: Leslie Brent
Publisher: Academic Press
Total Pages: 506
Release: 1996-11-18
Genre: Medical
ISBN: 008053399X

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Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career. Describes landmarks in immunology and places them in historical context Beautifully written by one of the founding fathers of the field Portrays the surprising history of events in a colorful and readable manner Contains biographical sketches of some of the pioneers Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation Foreword by Ray Owen

A History of Organ Transplantation

A History of Organ Transplantation
Author: David Hamilton
Publisher: University of Pittsburgh Pre
Total Pages: 577
Release: 2013-12-21
Genre: Medical
ISBN: 0822977842

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A History of Organ Transplantation is a comprehensive and ambitious exploration of transplant surgery—which, surprisingly, is one of the longest continuous medical endeavors in history. Moreover, no other medical enterprise has had so many multiple interactions with other fields, including biology, ethics, law, government, and technology. Exploring the medical, scientific, and surgical events that led to modern transplant techniques, Hamilton argues that progress in successful transplantation required a unique combination of multiple methods, bold surgical empiricism, and major immunological insights in order for surgeons to develop an understanding of the body's most complex and mysterious mechanisms. Surgical progress was nonlinear, sometimes reverting and sometimes significantly advancing through luck, serendipity, or helpful accidents of nature. The first book of its kind, A History of Organ Transplantation examines the evolution of surgical tissue replacement from classical times to the medieval period to the present day. This well-executed volume will be useful to undergraduates, graduate students, scholars, surgeons, and the general public. Both Western and non-Western experiences as well as folk practices are included.

Transplantation Immunology

Transplantation Immunology
Author: Philip Hornick
Publisher: Springer Science & Business Media
Total Pages: 430
Release: 2008-02-05
Genre: Medical
ISBN: 1597450499

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Leading clinicians and scientists in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The area of tolerance induction and reprogramming of the immune system is also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection.

Transplant Immunology

Transplant Immunology
Author: Xian C. Li
Publisher: John Wiley & Sons
Total Pages: 363
Release: 2015-11-16
Genre: Medical
ISBN: 0470658215

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With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field. Key chapters include: Transplant-related complications Immune responses to transplants Emerging issues in transplantation Biomarkers of Allograft rejection and tolerance T cells and the principles of immune responses In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.

Cellular Transplantation

Cellular Transplantation
Author: Craig Halberstadt
Publisher: Elsevier
Total Pages: 699
Release: 2011-10-10
Genre: Science
ISBN: 0080469043

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There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. Provides detailed description of clinical trials in cell transplantation Review of current therapeutic approaches Coverage of the broad range of diseases addressed by cell therapeutics Discussion of stem cell biology and its role in transplantation

Kidney Transplantation

Kidney Transplantation
Author: Peter J. Morris
Publisher: W.B. Saunders Company
Total Pages: 614
Release: 1984
Genre: Medical
ISBN:

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This fifth edition of KIDNEY TRANSPLANTATION remains the most comprehensive and definitive text on all aspects of renal transplantation as well as the psychological and ethical issues involved. Almost every chapter has been revised or rewritten by new authors, to incorporate the most essential and up-to-date information.

History Of Organ And Cell Transplantation

History Of Organ And Cell Transplantation
Author: Nadey S Hakim
Publisher: World Scientific
Total Pages: 464
Release: 2003-03-12
Genre: Medical
ISBN: 1783261803

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Organ transplantation is the greatest therapeutic advancement of the second half of the 20th century. Of all medical specialities, the pioneers of transplantation make up the largest number of experts awarded with, or nominated for the Nobel Prize.Over the years, transplantation has fascinated the scientific community as well as the general public for a variety of reasons:• The development of transplantation has involved almost all medical specialities. In the history of medicine, there is perhaps no other example of such extensive co-operation and exchange of knowledge and experience among basic scientists, surgeons and physicians in achieving a common goal.• The progress of transplantation has forced doctors to “rewrite” medical textbooks dealing with a great spectrum of post-transplantation issues, such as the physiology of transplanted organs, the recurrence of initial disease in the transplanted organs, and the complications arising from immunosuppressive drugs, infectious diseases and cancer. Other issues raised concern maternity, child development, geriatric medicine and ethical issues.However, the history of this amazing field of modern medicine has never been thoroughly reported in a detailed textbook. History of Organ and Cell Transplantation covers this area of modern literature. It includes a foreword written by Lady Jean Medawar who is the wife of the late Sir Peter Medawar, Nobel Prize winner and first president of the International Transplantation Society.

Transplantation at a Glance

Transplantation at a Glance
Author: Menna Clatworthy
Publisher: John Wiley & Sons
Total Pages: 116
Release: 2012-06-14
Genre: Medical
ISBN: 1118308549

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The first basic overview of all aspects of transplantation with a clarity not to be found in more inaccessible textbooks. This brand new title provides a succinct overview of both the scientific and clinical principles of organ transplantation and the types of organ transplant, featuring highly-illustrated information covering core topics in transplantation including: Organ donors Organ preservation Assessment of transplant recipients Indications for transplantation Immunology of transplantation Immunosuppression and its complications Overviews of thoracic and abdominal organ transplantation, including the kidneys, liver, heart and lungs Transplantation at a Glance is the ideal introduction for medical students, junior doctors, surgical trainees, immunology students, pharmacists, and nurses on transplant wards.

The Origins of Organ Transplantation

The Origins of Organ Transplantation
Author: Thomas Schlich
Publisher: University Rochester Press
Total Pages: 368
Release: 2010
Genre: History
ISBN: 1580463533

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This book investigates a crucial-but forgotten-episode in the history of medicine. In it, Thomas Schlich systematically documents and analyzes the earliest clinical and experimental organ transplant surgeries. In so doing he lays open the historical origins of modern transplantation, offering a new and original analysis of its conceptual basis within a broader historical context. This first comprehensive account of the birth of modern transplant medicine examines how doctors and scientists between 1880 and 1930 developed the technology and rationale for performing surgical organ replacement within the epistemological and social context of experimental university medicine. The clinical application of organ replacement, however, met with formidable obstacles even as the procedure became more widely recognized. Schlich highlights various attempts to overcome these obstacles, including immunological explanations and new technologies of immune suppression, and documents the changes in surgical technique and research standards that led to the temporary abandonment of organ transplantation by the 1930s. Thomas Schlich is professor and Canada Research Chair in the History of Medicine at McGill University.

A History of Immunology

A History of Immunology
Author: Arthur M. Silverstein
Publisher: Elsevier
Total Pages: 445
Release: 2012-12-02
Genre: Medical
ISBN: 0080925839

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This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline. A professional-level intellectual history of the development of immunology from about 1720 to 1970, with emphasis placed on the social climate of the scientific milieu in which modern immunology evolved Written by an author very well known both as a historian of medical science and for his substantial research contributions to the immunopathology of the eye The only complete history of immunology available