Between 1850 and 1906, La Crosse, Wisconsin, was typical of Mississippi River towns that received waves of Black settlers who followed the promise of an expanding frontier and available paths to that frontier. This work on Black La Crosse provides biographical sketches of recorded heads-of-household and families that lived in La Crosse during this half-century and presents data in comparative forms respecting residence, occupation, and personal information for all known persons of African decent who lived in La Crosse before 1906 and a narrative analysis of that data. The author also includes reproductions of three articles respecting La Crosse's Black experience, written for and published by the La Crosse County Historical Society in its magazine, Past, Present, & Future.