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| Author | : Marie-Paule Lefranc |
| Publisher | : Academic Press |
| Total Pages | : 420 |
| Release | : 2001-08-07 |
| Genre | : Medical |
| ISBN | : |
This reference for all functional and ORF T-cell receptor genes includes information on T-cell receptor structural and biological properties, chain synthesis, gene chromosomal localisation and T-cell receptor alpha, beta, gamma and delta.
| Author | : Marie-Paule Lefranc |
| Publisher | : Elsevier |
| Total Pages | : 413 |
| Release | : 2001-07-13 |
| Genre | : Medical |
| ISBN | : 0080542646 |
The T Cell Receptor FactsBook contains entries on all the 176 functional variable, diversity, joining, and constant regions of the human T cell receptor, including alpha, beta, gamma, and delta loci. Introductory chapters summarize information of T cell receptor chain synthesis, chromosomal location, and an overview of the human T cell receptor loci.
| Author | : Marie-Paule Lefranc |
| Publisher | : Academic Press |
| Total Pages | : 472 |
| Release | : 2001-05-23 |
| Genre | : Medical |
| ISBN | : 0080574475 |
The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field.The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.
| Author | : Tak W. Mak |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 243 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1468454064 |
The importance of thymus-dependent cells, or T cells, in the generation of a successful immune response was first realized in the early sixties. In the follow ing two decades, a succession of elegant experiments established the antigen specificity of T cells and their ability to perform both as regulatory and effector cells. T cells were shown to be essential in most immune reactions, playing a crucial role in augmenting the activity of effector T and B cells against 'foreign' antigen, as well as in the suppression of effector activity against self antigens. The means by which T cells differentiate 'foreign' from 'self' antigens is based on their recognition of antigen almost exclusively in the context of self major histocompatibility complex products, unlike B cells, which recognize an tigen alone. It is this recognition, mediated by the T-cell receptor, that sets into motion the diverse cell-cell interactions, which control the differentiation and regulation of the immune response. Although its importance was well established, the molecular nature of the T-cell receptor remained elusive for two decades. Many hypotheses as to its structure and precise function were put forward, using immunoglobulin as a basis for conjecture, but "the Holy Grail of Immunology" remained ephemeral until three years ago. In the ensuing years, both immunologists and molecular biologists have contributed to an explosion of data unsurpassed by any previous period in the field.
| Author | : Christian Schönbach |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 216 |
| Release | : 2007-11-21 |
| Genre | : Medical |
| ISBN | : 0387729682 |
In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.
| Author | : Krishna Vaddi |
| Publisher | : Elsevier |
| Total Pages | : 219 |
| Release | : 1997-04-01 |
| Genre | : Medical |
| ISBN | : 0080529089 |
How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalog of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy-to-follow format. Taken together they compile everything you want to know about proteins but are too busy to look for. The Chemokine FactsBook contains more than 40 entries on chemokines, and chemokine receptors from human or other origin, including IL-8, MCP-1, C5-a, RANTES, Lymphotactin, and CC CKR-1. The text provides information on tissue sources, target cells, physicochemical properties, transcription factors, regulation of expression in disease, receptor-binding characteristics, gene structure and location, amino acid sequences, and accession numbers and references. Contains over 40 entries on chemokines and chemokine receptors from human or other origin, including: IL-8 MCP-1 C5-a RANTES Lymphotactin CC CKR-1 Entries provide information on: Tissue sources Target cells Physicochemical properties Transcription factors Regulation of expression Expression in disease Receptor-binding characteristics Gene structure and location Amino acid sequences Database accession numbers References
| Author | : John I. Bell |
| Publisher | : |
| Total Pages | : 522 |
| Release | : 1995 |
| Genre | : Medical |
| ISBN | : |
T cell receptor genes covers biochemical, functional and genetic aspects of this key family of immunological molecules. It should be essential reading for all those interested in the TCR and its function in health and disease. It deals with the TCR protein, its functional interactions with the signal transduction machinery of the T cell and with the structure and organization of the TCR genes. It is the only comprehensive volume on the TCR and is written by leaders in the field. Particularly useful is the tabulation and nomenclature of all the known TCR alpha and beta variable regions.
| Author | : Jorge R. Oksenberg |
| Publisher | : Kluwer Academic Publishers |
| Total Pages | : 0 |
| Release | : 1997 |
| Genre | : T cells |
| ISBN | : 9780412126413 |
| Author | : Almurdi |
| Publisher | : |
| Total Pages | : 68 |
| Release | : 1992 |
| Genre | : |
| ISBN | : |
| Author | : Hans G. Drexler |
| Publisher | : Academic Press |
| Total Pages | : 751 |
| Release | : 2000-09-04 |
| Genre | : Medical |
| ISBN | : 0080535445 |
The Leukemia-Lymphoma Cell Line Factsbook represents an essential reference manual for all of the well-characterized leukemia-lymphoma cell lines currently available. It provides the most important facts, using the succinct and user-friendly format that has made the FactsBooks so popular with scientists and clinical researchers. Introductory chapters provide background and perspective for culturing malignant hematopoietic (blood forming) cell lines. These chapters are followed by over 400 comprehensive individual entries. Each cell line entry highlights essential clinical, immunological, genetic, and functional features and includes a comprehensive listing of references. The full spectrum of malignant cell lines from all hematopoietic cell lineages Sister cell lines and relevant subclones Clinical data: patient, diagnosis, treatment status, and specimen source Authentication of derivation and availability Immunophenotype Cytogenetic karyotype Translocations and fusion genes Receptor gene rearrangements and genetic alterations Cell cultures aspects: establishment, medium, doubling time, growth Cytochemical profile Cytokine production and response to cytokines Proto-oncogene and transcription factor expression/alteration Functional features: differentiation induction, heterotransplantability Special unique features Key references
