Synthesis and Coordination Chemistry of a New (mercaptoimidazolyl)pyridine Ligand
Author | : Jessica Lauren Bongiovanni |
Publisher | : |
Total Pages | : 248 |
Release | : 2011 |
Genre | : |
ISBN | : |
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A new mixed-donor ligand containing both pyridine and thione donor groups, o-(3-methyl-2-mercaptoimidazolyl)pyridine (o-mpyMe), has been synthesized. The ligand has good solubility and stability in organic solvents, as well as partial solubility in water. The coordination chemistry of this new ligand with metals such as manganese(I), rhenium(I), cobalt(II), nickel(II), copper(I), silver(I), zinc(II), cadmium(II), mercury(II), indium(III), antimony(III) and bismuth(III), leading to an assortment of coordination modes and reactivity. Most significantly, copper(I) complexes of o-mpyMe were prepared with the aim of generating potential synthetic analogues of the metal center in methanobactin, a copper-binding compound. Methanobactin (mb) is responsible for the uptake and transport of copper to the enzyme methane monooxygenase (MMO), which oxidizes methane gas to methanol in the global carbon cycle. The active site of mb consists of a tetrahedral Cu(I) center with N2S2 coordination. Characterization, reactivity and biological activity of [Cu(o-mpyMe)2]X (X = BF4, PF6) to determine if these complexes are viable analogues of methanobactin has been carried out.