Recombinant Human Erythropoietin Rhepo In Clinical Oncology
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Author | : Mohammad Resa Nowrousian |
Publisher | : Springer Science & Business Media |
Total Pages | : 524 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3709176581 |
Download Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology Book in PDF, Epub and Kindle
Anemia is a frequent complication of cancer and its treatment. A number of clinical studies shows that the impact of anemia is much greater than previously thought. Beyond clinical symptoms, anemia significantly impairs physical and metabolic functions as well as patients' activity, well-being and quality of life. Life expectancy is also affected. In this book, written by a group of outstanding international experts, the current knowledge on anemia in cancer and its treatment with rhEPO is presented. Future developments are also discussed. Based on a broad spectrum of topics, the book describes the scientific and clinical aspects of anemia in various fields of oncology and gives diagnostic and therapeutic recommendations on when and how to use rhEPO.
Author | : Wolfgang Jelkmann |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 32 |
Release | : 2013-05-07 |
Genre | : Science |
ISBN | : 0128062002 |
Download Introduction to Biological and Small Molecule Drug Research and Development Book in PDF, Epub and Kindle
The renal hormone erythropoietin (Epo) is essential for the viability and proliferation of the erythrocytic progenitors generating reticulocytes in the bone marrow. Human Epo consists of a chain of 165 amino acid residues and four glycans. The synthesis of Epo is strongly stimulated by hypoxia. Epo deficiency is the primary cause of the anaemia in chronic kidney disease (CKD). For anaemia treatment recombinant human Epo (rhEpo/epoetin and epoetin) is very useful. The drug substance is generally manufactured in EPO complementary DNA (cDNA) transfected Chinese hamster ovary cell cultures. rhEpo therapy is beneficial not only for CKD patients but also for anaemic cancer patients receiving chemotherapy. The expiry of the patents for the first original rhEpo formulations has initiated the production of similar biological medicinal products (‘biosimilars’). The term ‘biosimilar’ should only be used for a medicinal product approved on a strict regulatory pathway (i.e. European Medicines Agency, Food and Drug Administration, etc.). Unfortunately, many claimed ‘biosimilars’ have not been through an approval authority. Furthermore, rhEpo analogues with prolonged survival in circulation (‘biobetter’) have been developed and synthetic Epo mimetic peptides have been developed for therapy. The biological role of Epo outside the bone marrow is the focus of current research.
Author | : Christian Bauer |
Publisher | : CRC Press |
Total Pages | : 488 |
Release | : 1993-09-23 |
Genre | : Medical |
ISBN | : 9780824791391 |
Download Erythropoietin Book in PDF, Epub and Kindle
Presents the proceedings of the Fourth International Workshop on Recombinant Human Erythropoietin (rhEPO). The work examines the treatment of renal anaemia with rhEPO, the use of rhEPO in elective surgery and rhEPO in the therapy of neoplastic disease.
Author | : Edson Sydney de Campos |
Publisher | : |
Total Pages | : 219 |
Release | : 1992 |
Genre | : |
ISBN | : |
Download Clinical and Cell Cultures Studies of the Effects of Recombinant Human Erythropoietin in Small Cell Lung Cancer Patients Receiving Intensive Chemotherapy Book in PDF, Epub and Kindle
Author | : Canadian Hematology Society |
Publisher | : Mississauga, Ont. : MES Medical Education Services (Canada) |
Total Pages | : 18 |
Release | : 1989 |
Genre | : Anemia |
ISBN | : 9780886611590 |
Download The Clinical Use of Recombinant Human Erythropoietin : a Report of a Symposium Book in PDF, Epub and Kindle
Author | : Carsten Nieder |
Publisher | : Springer Science & Business Media |
Total Pages | : 308 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642556132 |
Download Modification of Radiation Response Book in PDF, Epub and Kindle
This book describes and summarizes the radiation responses of both normal and neoplastic tissues with a focus on rational strategies for the modification of these responses. Emerging data from molecular oncology and radiobiology are reviewed in depth. The book covers not only general principles of radiation-induced reactions but also a large number of preclinical and clinical data that will guide the reader through this complex and dynamic field and will provide valuable information for the development of further research projects.
Author | : Horst Pagel |
Publisher | : Springer Science & Business Media |
Total Pages | : 318 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642770746 |
Download Pathophysiology and Pharmacology of Erythropoietin Book in PDF, Epub and Kindle
The book contains a series of about 40 articles reflecting the state-of-the-art of the topic "Pathophysiology and Pharmacology of Erythropoietin". Results from both basic research and clinical studies are described in detail. The papers show that the possible therapeutic spectrum of erythropoietin could be expanded considerably when compared with the present situation.
Author | : Steven G. Elliott |
Publisher | : Springer Science & Business Media |
Total Pages | : 337 |
Release | : 2009-06-05 |
Genre | : Medical |
ISBN | : 3764386983 |
Download Erythropoietins, Erythropoietic Factors, and Erythropoiesis Book in PDF, Epub and Kindle
A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators.
Author | : Felix Kratz |
Publisher | : John Wiley & Sons |
Total Pages | : 1828 |
Release | : 2013-09-30 |
Genre | : Medical |
ISBN | : 3527647759 |
Download Drug Delivery in Oncology Book in PDF, Epub and Kindle
In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.
Author | : Clemens Fritsch |
Publisher | : Springer Science & Business Media |
Total Pages | : 144 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3709160464 |
Download Fluorescence Diagnosis and Photodynamic Therapy of Skin Diseases Book in PDF, Epub and Kindle
This book is the most up-to-date publication on fluorescence diagnostic (FDAP) and photodynamic therapy (PDT) methods used in dermatology. Both techniques are presently world wide introduced as standards for the delineation and the treatment of cutaneous precancerous stages and tumors, which show steadily increasing numbers due to e.g. more frequent sun exposure. Summarizing experiences on more than 5.000 treated patients, it offers a comprehensive information on every aspect of skin tumor detection and treatment. The main part of the book focuses on the clinical aspects giving detailed descriptions on skin tumor detection as well as photodynamic treatment of selected diseases (solar keratoses, basal cell carcinomas, squamous cell carcinomas, Bowen's disease, psoriasis lesions, etc.). The clinically oriented chapters are supplemented by practical guidelines for PDT and FDAP. The included atlas is comprised of 270 high quality color figures allowing daily use as a handbook.