Reactivity Of Chelated Dinuclear Platinumii Complexes
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Author | : Allen Mambanda |
Publisher | : LAP Lambert Academic Publishing |
Total Pages | : 252 |
Release | : 2012 |
Genre | : |
ISBN | : 9783847378907 |
Download Reactivity of Chelated Dinuclear Platinum(ii) Complexes Book in PDF, Epub and Kindle
The search for new Pt(II) metal drugs is underpinned by an in-depth understanding of the factors controlling the bio-reactivity of the Pt(II) pharmaceuticals. An emerging class of compounds which has shown improved antitumour activity is the multinuclear Pt(II) complexes, epitomized by the favourable reactivity profile of BBR3464 from Prof. Farrell's labs. Kinetic data of multinuclear Pt(II) compounds is not extensive. This book, reports the substitution reactions of bis(2-pyridylmethyl)amine-chelated dinuclear Pt(II) complexes linked by diamine bridges. The reactions were studied under pseudo first-order conditions as a function of concentration of nucleophiles and temperature using stopped-flow and UV-visible spectroscopic techniques. In general, the substitution of the coligand by the sulfur containing nucleophiles proceeds via a two-step reaction pathway which is associatively activated. In the studied sets of Pt(II) dinuclears, substitution of the coligands is controlled mainly by steric effects, derived from the molecular conformations of the metal complexes and to a lesser extent by electronic effects. Experimental data is well supported by Quantum mechanical calculations.
Author | : Allen Mambanda |
Publisher | : |
Total Pages | : 319 |
Release | : 2009 |
Genre | : Chelates |
ISBN | : |
Download Influence of Bridging Groups on the Reactivity of Dinuclear Platinum (II) Complexes with Bis(2-pyridylmethyl)amine Chelate Headgroups Book in PDF, Epub and Kindle
Author | : Stephanie Hochreuther |
Publisher | : |
Total Pages | : 16 |
Release | : 2012 |
Genre | : |
ISBN | : |
Download Synthesis and Reactivity of Dinuclear Platinum(II)-complexes Containing Bidentate N,N- and N,S-donor Ligands Book in PDF, Epub and Kindle
Author | : Peter Olengo Ongoma |
Publisher | : |
Total Pages | : |
Release | : 2012 |
Genre | : Chemotherapy |
ISBN | : |
Download Tuning Reactivity of Platinum(II) Complexes Book in PDF, Epub and Kindle
Author | : Pablo Oppezzo |
Publisher | : BoD – Books on Demand |
Total Pages | : 466 |
Release | : 2012-02-10 |
Genre | : Medical |
ISBN | : 9533078812 |
Download Chronic Lymphocytic Leukemia Book in PDF, Epub and Kindle
B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinical aggressiveness and prognosis. As CLL progresses, abnormal hematopoiesis results in pancitopenia and decreased immunoglobulin production, followed by nonspecific symptoms such as fatigue or malaise. A cure is usually not possible, and delayed treatment (until symptoms develop) is aimed at lengthening life and decreasing symptoms. Researchers are playing a lead role in investigating CLL's cause and the role of genetics in the pathogenesis of this disorder. Research programs are dedicated towards understanding the basic mechanisms underlying CLL with the hope of improving treatment options.
Author | : Subhangi Roy |
Publisher | : |
Total Pages | : 189 |
Release | : 2018 |
Genre | : |
ISBN | : |
Download Design, Synthesis and Photophysical Properties of Dinuclear Platinum (II) Complexes with Varying Bridging and Cyclometalating Ligands Book in PDF, Epub and Kindle
Author | : Skylar Ferrara |
Publisher | : |
Total Pages | : 0 |
Release | : 2007 |
Genre | : Chemical reactions |
ISBN | : |
Download Synthesis and reactivity of platinum(II)-ruthenium(II)/(III) heterotrinuclear and heterodinuclear complexes and their precursors with the small, biomimetic molecules nitric oxide and imidazole Book in PDF, Epub and Kindle
Author | : Pui-Ling Tang |
Publisher | : |
Total Pages | : |
Release | : 2017-01-27 |
Genre | : |
ISBN | : 9781374783775 |
Download Synthesis, Luminescence and Host-Guest Chemistry of Mono- and Dinuclear Platinum(ii) Complexes of Pyridyl and Diphosphine Ligands Book in PDF, Epub and Kindle
Author | : Samuel A. Bryan |
Publisher | : |
Total Pages | : 284 |
Release | : 1985 |
Genre | : Chemical reactions |
ISBN | : |
Download Thermal, Photochemical and Electrochemical Reactions on Dinuclear Platinum(III) Complexes Book in PDF, Epub and Kindle
Author | : Hakan Ertürk |
Publisher | : |
Total Pages | : 111 |
Release | : 2009 |
Genre | : |
ISBN | : |
Download Synthesis and Reactivity Tuning of Novel Dinuclear Pt(II)-complexes with Potential Cytostatic Activity Book in PDF, Epub and Kindle