Proteins and Proteomics of Leishmania and Trypanosoma

Proteins and Proteomics of Leishmania and Trypanosoma
Author: André L.S. Santos
Publisher: Springer Science & Business Media
Total Pages: 387
Release: 2013-11-22
Genre: Medical
ISBN: 9400773056
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This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteomics of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.

Molecular and Cellular Biology of Pathogenic Trypanosomatids

Molecular and Cellular Biology of Pathogenic Trypanosomatids
Author: Marcelo Santos da Silva
Publisher: Bentham Science Publishers
Total Pages: 612
Release: 2017-02-16
Genre: Medical
ISBN: 1681084058
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Frontiers in Parasitology is an Ebook series devoted to publishing the latest and the most important advances in parasitology. Eminent scientists present reviews on the microbiology, cytology, epidemiology, genomics, and molecular biology of microbial parasites and their associated infections. Additionally, the series also gives information about new diagnostic and therapeutic protocols. The Ebook series is essential reading to all scientists involved in studying harmful microbes and their impact on human health.

Trypanosomiasis and Leishmaniasis

Trypanosomiasis and Leishmaniasis
Author: Katherine Elliott
Publisher: John Wiley & Sons
Total Pages: 192
Release: 2009-09-16
Genre: Medical
ISBN: 047071770X
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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Drug Targets in Kinetoplastid Parasites

Drug Targets in Kinetoplastid Parasites
Author: Hemanta K. Majumder
Publisher: Springer Science & Business Media
Total Pages: 174
Release: 2008-09-15
Genre: Medical
ISBN: 0387775706
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The dreaded protozoal diseases caused by a number of Kinetoplastid parasites threaten mankind, as therapeutic tools for the treatment of most parasitic diseases are extremely limited. Development of commercially available vaccines is still far from reality, though research and trial programs continue. This book covers current research into drug therapeutics for the conditions caused by the parasites, which if viewed globally, pose an increasing threat to human health and welfare.

Trypanosomiasis and Leishmaniasis

Trypanosomiasis and Leishmaniasis
Author: Geoff Hide
Publisher:
Total Pages: 392
Release: 1997
Genre: Medical
ISBN:
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Trypanosomiasis and Leishmaniasis are related diseases caused by single celled organisms (protozoa) transmitted by insects. Between them, these diseases are responsible for much suffering among humans and livestock and so a greater understanding of their biology is a vital part of the campaign to control them. Modern molecular techniques available for use in understanding the control of these diseases are becoming more sophisticated and are increasingly becoming universally applicable to a wide variety of diseases. This book brings together the research approaches that are used interchangeably to understand both Trypanosomiasis and Leishmaniasis. Examples of such fruitful integration can be seen in a number of research areas: genome mapping, molecular and population genetic approaches to epidemiology, studies on polyamine metabolism and possible targets for rational drug design, studies on cellular signalling as a route to understanding host-parasite interactions and studies on chemotherapy and drug resistance. There are also chapters that consider those features that are unique to either Trypanosomiasis or Leishmaniasis. Thus a broad overview of the biology of each disease from the molecular level right up to the whole animal is provided. Contributors come from the leading research groups working on these diseases and include clinicians, laboratory based researchers and social scientists. The book provides an up-to-date summary of the advances in the understanding of these diseases that have come about through the use of modern technologies. By presenting an integration of research into both Trypanosomiasis and Leishmaniasis this book provides an innovative contribution to the literature in this area. It is important reading for all parasitologists, pharmacologists, epidemiologists and clinicians working with these organisms. It is also a useful resource for veterinarians, public health workers, policy makers and social scientists concerned with Trypanosomiasis or Leishmaniasis.

Mass Spectrometry-Based Chemical Proteomics

Mass Spectrometry-Based Chemical Proteomics
Author: W. Andy Tao
Publisher: John Wiley & Sons
Total Pages: 448
Release: 2019-07-10
Genre: Science
ISBN: 1118970217
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PROVIDES STRATEGIES AND CONCEPTS FOR UNDERSTANDING CHEMICAL PROTEOMICS, AND ANALYZING PROTEIN FUNCTIONS, MODIFICATIONS, AND INTERACTIONS—EMPHASIZING MASS SPECTROMETRY THROUGHOUT Covering mass spectrometry for chemical proteomics, this book helps readers understand analytical strategies behind protein functions, their modifications and interactions, and applications in drug discovery. It provides a basic overview and presents concepts in chemical proteomics through three angles: Strategies, Technical Advances, and Applications. Chapters cover those many technical advances and applications in drug discovery, from target identification to validation and potential treatments. The first section of Mass Spectrometry-Based Chemical Proteomics starts by reviewing basic methods and recent advances in mass spectrometry for proteomics, including shotgun proteomics, quantitative proteomics, and data analyses. The next section covers a variety of techniques and strategies coupling chemical probes to MS-based proteomics to provide functional insights into the proteome. In the last section, it focuses on using chemical strategies to study protein post-translational modifications and high-order structures. Summarizes chemical proteomics, up-to-date concepts, analysis, and target validation Covers fundamentals and strategies, including the profiling of enzyme activities and protein-drug interactions Explains technical advances in the field and describes on shotgun proteomics, quantitative proteomics, and corresponding methods of software and database usage for proteomics Includes a wide variety of applications in drug discovery, from kinase inhibitors and intracellular drug targets to the chemoproteomics analysis of natural products Addresses an important tool in small molecule drug discovery, appealing to both academia and the pharmaceutical industry Mass Spectrometry-Based Chemical Proteomics is an excellent source of information for readers in both academia and industry in a variety of fields, including pharmaceutical sciences, drug discovery, molecular biology, bioinformatics, and analytical sciences.

The Leishmaniases: Old Neglected Tropical Diseases

The Leishmaniases: Old Neglected Tropical Diseases
Author: Fabrizio Bruschi
Publisher: Springer
Total Pages: 249
Release: 2018-01-12
Genre: Medical
ISBN: 3319723863
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Out of the 20 neglected tropical diseases (NTDs) prioritized by the World Health Organization, the leishmaniases rank in the top 3 among those caused by protozoa. The purpose of this book is to provide the reader with a comprehensive and updated overview of all the aspects of leishmaniasis with a worldwide perspective – authors of many chapters include eminent scientists from both the Old and New Worlds. The chapters cover a wide range of topics, classically organized into biology and epidemiology, followed by clinical and control aspects. Following an introductory chapter intended to take the reader into the leishmaniasis complexity, a chapter on Leishmania taxonomy reports on the most recent advances in molecular and phylogenetic data. Parasite biology is then described in detail by means of two separate chapters devoted to phlebotomine vectors and reservoir hosts, respectively. The medical part of the book begins with a chapter on basic immunology and immunopathology associated with Leishmania infection, followed by a classical chapter on clinical aspects of different disease entities. The complexity of disease case management is presented by means of 3 chapters, respectively on diagnosis, treatment of visceral forms and treatment of tegumentary forms. Finally, the last chapter deals with the available approaches to control leishmaniasis and related public health issues.

American Trypanosomiasis

American Trypanosomiasis
Author: Jenny Telleria
Publisher: Elsevier
Total Pages: 871
Release: 2010-09-03
Genre: Medical
ISBN: 0123848776
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Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. American Trypanosomiasis provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: The host: human and mammalian reservoirs The insect vectors: domestic and sylvatic vectors The causative parasite: Trypanosoma cruzi Informs and updates on all the latest developments in the field Contributions from leading authorities and industry experts