Proteins And Proteomics
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Author | : André L.S. Santos |
Publisher | : Springer Science & Business Media |
Total Pages | : 387 |
Release | : 2013-11-22 |
Genre | : Medical |
ISBN | : 9400773056 |
Download Proteins and Proteomics of Leishmania and Trypanosoma Book in PDF, Epub and Kindle
This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteomics of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.
Author | : Oscar Alzate |
Publisher | : CRC Press |
Total Pages | : 356 |
Release | : 2009-10-26 |
Genre | : Medical |
ISBN | : 1420076264 |
Download Neuroproteomics Book in PDF, Epub and Kindle
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Author | : Richard J. Simpson |
Publisher | : CSHL Press |
Total Pages | : 946 |
Release | : 2003 |
Genre | : Proteins |
ISBN | : 9780879695545 |
Download Proteins and Proteomics Book in PDF, Epub and Kindle
Introduction to proteomics; one-dimensional polyacrylamide gel electrophoresis; preparing cellular and subcellular extracts; preparative two-dimensional gel electrophoresis with immobilized pH gradients; reversed-phase high -performance liquid chromatography; amino- and carboxy-terminal sequence analysis; peptide mapping and sequence analysis of gel-resolved proteins; the use of mass spectrometry in proteomics; proteomic methods for phosphorylation site mapping; characterization of protein complexes; making sense of proteomics - using bioinformatics to discover a protein's structure, functions, and interactions.
Author | : Tsz Kwong Man |
Publisher | : BoD – Books on Demand |
Total Pages | : 454 |
Release | : 2012-02-10 |
Genre | : Science |
ISBN | : 9533078324 |
Download Proteomics Book in PDF, Epub and Kindle
Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field. This book covers four important and diverse areas of current proteomic research: Proteomic Discovery of Disease Biomarkers, Proteomic Analysis of Protein Functions, Proteomic Approaches to Dissecting Disease Processes, and Organelles and Secretome Proteomics. We believe that clinicians, students and laboratory researchers who are interested in Proteomics and its applications in the biomedical field will find this book useful and enlightening. The use of proteomic methods in studying proteins in various human diseases has become an essential part of biomedical research.
Author | : Eric D. Merkley |
Publisher | : |
Total Pages | : 248 |
Release | : 2020-10-09 |
Genre | : Law |
ISBN | : 9780841236493 |
Download Applications in Forensic Proteomics Book in PDF, Epub and Kindle
Introduction to forensic proteomics -- A proteomics tutorial -- Proteomic sample preparation techniques : toward forensic proteomic applications -- NextGen serology : leveraging mass spectrometry for protein-based human body fluid identification -- Informatics approaches to forensic body fluid identification by proteomic mass spectrometry -- Fingermarks as a new proteomic specimen : state of the art and perspective of in situ proteomics -- Human identification using genetically variant peptides in biological forensic evidence -- Proteomics in the analysis of forensic, archaeological, and paleontological bone -- Proteomics for microbial forensics -- ISO 17025 accreditation of method-based mass spectrometry for bioforensic analyses -- Unambiguous identification of ricin and abrin with advanced mass spectrometric assays -- Challenges in the development of reference materials for protein toxins -- The statistical defensibility of forensic proteomics.
Author | : Eric Bertrand |
Publisher | : Springer Science & Business Media |
Total Pages | : 397 |
Release | : 2007-08-29 |
Genre | : Science |
ISBN | : 1402059434 |
Download Subcellular Proteomics Book in PDF, Epub and Kindle
This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
Author | : Sanjeeva Srivastava |
Publisher | : CRC Press |
Total Pages | : 272 |
Release | : 2022-12-29 |
Genre | : Medical |
ISBN | : 1000648672 |
Download From Proteins to Proteomics Book in PDF, Epub and Kindle
Proteomics aims to study all the proteins of human and other living systems, as well as their properties to provide an integrated view of cellular processes. The study of proteomics involves the application of rapidly evolving high-throughput technologies and new platforms that are coming forward regularly, providing versatile novel tools for biomedical and pharmaceutical applications. This book provides a detailed understanding of the basics of proteins and proteomics, gel based-proteomics techniques, basics of mass spectrometry and quantitative proteomics, interactomics: basics and applications, and advancements in proteomics. It also covers basic knowledge about sample preparation, mass spectrometry workflow, different chromatography technologies and quantitative proteomics. The text highlights the application and challenges of various high-throughput integrated proteomics technologies capable of fast and accurate screening of thousands of biomolecules, which are found to be very effective for studying disease pathobiology and identification of next-generation biomarkers and potential drug/vaccine targets; and are therefore considered valuable tools for multidisciplinary research. Features Basics of proteins and proteomics techniques In-depth understanding of mass spectrometry and quantitative proteomics An overview of interactomics and its application for translational research Advancement in the field of proteomics and challenges in clinical applications We hope the knowledge gained from reading this book will intrigue and motivate young minds to explore future opportunities in the constantly evolving field of proteomics.
Author | : Hubert Rehm |
Publisher | : Academic Press |
Total Pages | : 252 |
Release | : 2006 |
Genre | : Science |
ISBN | : 012088545X |
Download Protein Biochemistry and Proteomics Book in PDF, Epub and Kindle
An innovative, tactical, guide to avoid frustration in the biochemical lab!
Author | : Richard J. Simpson |
Publisher | : |
Total Pages | : 926 |
Release | : 2003 |
Genre | : Proteins |
ISBN | : 9787030119124 |
Download 蛋白质与蛋白质组学实验指南 Book in PDF, Epub and Kindle
本书提供了一系列可操作性强、行之有效的实验方案对蛋白质进行分离、鉴定、定量及功能分析,也有适于分析蛋白质结构包括电泳及色谱制备分析的方法,以及蛋白质芯片和生物信息学的相关内容。
Author | : Richard Twyman |
Publisher | : Garland Science |
Total Pages | : 266 |
Release | : 2004-05-01 |
Genre | : Science |
ISBN | : 0203507398 |
Download Principles of Proteomics Book in PDF, Epub and Kindle
Principles of Proteomics is designed specifically to explain the different stages of proteomic analysis, their complexities and their jargon to students and researchers in a non-technical overview of the field. The author describes the broad range of problems which proteomics can address, including structural proteomics, interaction proteomics, protein modification analysis and functional proteomics. Methodologies are described in user-friendly language, from the more traditional two-dimensional gel electrophoresis to the new developments in protein chip technologies. These are well presented in the context of overall strategies which can be adopted to address the different aspects of large-scale protein analysis.