The objective of this research was to investigate the performance of two-phase spray cooling with HFC-134a and HFO-1234yf refrigerants using practical enhanced heat transfer surfaces. Results of the study were expected to provide a quantitative spray cooling performance comparison with working fluids representing the current and next-generation mobile air conditioning refrigerants, and demonstrate the feasibility of this approach as an alternative active cooling technology for the thermal management of high heat flux power electronics (i.e., IGBTs) in electric-drive vehicles. Potential benefits of two-phase spray cooling include achieving more efficient and reliable operation, as well as compact and lightweight system design that would lead to cost reduction. The experimental work involved testing of four different enhanced boiling surfaces in comparison to a plain reference surface, using a commercial pressure-atomizing spray nozzle at a range of liquid flow rates for each refrigerant to determine the spray cooling performance with respect to heat transfer coefficient (HTC) and critical heat flux (CHF). The heater surfaces were prepared using dual-stage electroplating, brush coating, sanding, and particle blasting, all featuring "practical" room temperature processes that do not require specialized equipment. Based on the obtained results, HFC-134a provided a better heat transfer performance through higher HTC and CHF values compared to HFO-1234yf at all tested surfaces and flow rates. While majority of the tested surfaces provided comparable HTC and modestly higher CHF values compared to the reference surface, one of the enhanced surfaces offered significant heat transfer enhancement.