Neural Computation in the Context of Upstream Dynamics in the Retina

Neural Computation in the Context of Upstream Dynamics in the Retina
Author: Philip R. Mardoum
Publisher:
Total Pages: 83
Release: 2021
Genre:
ISBN:

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To understand neural circuit function, one would like to understand individual neurons' computation in the context of their physiological inputs. But these inputs are themselves subject to complex dynamics, and we rarely have tools to experimentally control synaptic inputs under physiological conditions that preserve their temporal features. Primary sensory structures present an exception because primary receptor neurons can be controlled experimentally under physiological conditions. Here, I present work carried out in the retina, where signaling by photoreceptors (the primary receptor neurons in vision) has been characterized in detail and can be controlled with light, and computation in downstream circuitry can therefore be investigated in the context of physiological input from photoreceptors. I first present a hybrid biophysical-statistical model of retinal output that disentangles the computational contributions of photoreceptors from those of other circuit elements and successfully predicts retinal ganglion cell responses to stimuli with dynamically changing statistics. Second, I present an investigation of synaptic specializations that could mediate parallel processing of input from different photoreceptor types within individual post-synaptic neurons.

Retinal Computation

Retinal Computation
Author: Greg Schwartz
Publisher: Academic Press
Total Pages: 342
Release: 2021-08-07
Genre: Medical
ISBN: 0128231777

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Retinal Computation summarizes current progress in defining the computations performed by the retina, also including the synaptic and circuit mechanisms by which they are implemented. Each chapter focuses on a single retinal computation that includes the definition of the computation and its neuroethological purpose, along with the available information on its known and unknown neuronal mechanisms. All chapters contain end-of-chapter questions associated with a landmark paper, as well as programming exercises. This book is written for advanced graduate students, researchers and ophthalmologists interested in vision science or computational neuroscience of sensory systems. While the typical textbook's description of the retina is akin to a biological video camera, the real retina is actually the world’s most complex image processing machine. As part of the central nervous system, the retina converts patterns of light at the input into a rich palette of representations at the output. The parallel streams of information in the optic nerve encode features like color, contrast, orientation of edges, and direction of motion. Image processing in the retina is undeniably complex, but as one of the most accessible parts of the central nervous system, the tools to study retinal circuits with unprecedented precision are up to the task. This book provides a practical guide and resource about the current state of the field of retinal computation. Provides a practical guide on the field of retinal computation Summarizes and clearly explains important topics such as luminance, contrast, spatial features, motion and other computations Contains discussion questions, a landmark paper, and programming exercises within each chapter

Process Dynamics and Control

Process Dynamics and Control
Author: Dale E. Seborg
Publisher: John Wiley & Sons
Total Pages: 512
Release: 2016-09-13
Genre: Technology & Engineering
ISBN: 1119285917

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The new 4th edition of Seborg’s Process Dynamics Control provides full topical coverage for process control courses in the chemical engineering curriculum, emphasizing how process control and its related fields of process modeling and optimization are essential to the development of high-value products. A principal objective of this new edition is to describe modern techniques for control processes, with an emphasis on complex systems necessary to the development, design, and operation of modern processing plants. Control process instructors can cover the basic material while also having the flexibility to include advanced topics.

Dynamics in Action

Dynamics in Action
Author: Alicia Juarrero
Publisher: MIT Press
Total Pages: 306
Release: 2002-01-25
Genre: Psychology
ISBN: 9780262600477

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What is the difference between a wink and a blink? The answer is important not only to philosophers of mind, for significant moral and legal consequences rest on the distinction between voluntary and involuntary behavior. However, "action theory"—the branch of philosophy that has traditionally articulated the boundaries between action and non-action, and between voluntary and involuntary behavior—has been unable to account for the difference. Alicia Juarrero argues that a mistaken, 350-year-old model of cause and explanation—one that takes all causes to be of the push-pull, efficient cause sort, and all explanation to be prooflike—underlies contemporary theories of action. Juarrero then proposes a new framework for conceptualizing causes based on complex adaptive systems. Thinking of causes as dynamical constraints makes bottom-up and top-down causal relations, including those involving intentional causes, suddenly tractable. A different logic for explaining actions—as historical narrative, not inference—follows if one adopts this novel approach to long-standing questions of action and responsibility.

Biologically Inspired Computer Vision

Biologically Inspired Computer Vision
Author: Gabriel Cristobal
Publisher: John Wiley & Sons
Total Pages: 482
Release: 2015-11-16
Genre: Technology & Engineering
ISBN: 3527412646

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As the state-of-the-art imaging technologies became more and more advanced, yielding scientific data at unprecedented detail and volume, the need to process and interpret all the data has made image processing and computer vision increasingly important. Sources of data that have to be routinely dealt with today's applications include video transmission, wireless communication, automatic fingerprint processing, massive databanks, non-weary and accurate automatic airport screening, robust night vision, just to name a few. Multidisciplinary inputs from other disciplines such as physics, computational neuroscience, cognitive science, mathematics, and biology will have a fundamental impact in the progress of imaging and vision sciences. One of the advantages of the study of biological organisms is to devise very different type of computational paradigms by implementing a neural network with a high degree of local connectivity. This is a comprehensive and rigorous reference in the area of biologically motivated vision sensors. The study of biologically visual systems can be considered as a two way avenue. On the one hand, biological organisms can provide a source of inspiration for new computational efficient and robust vision models and on the other hand machine vision approaches can provide new insights for understanding biological visual systems. Along the different chapters, this book covers a wide range of topics from fundamental to more specialized topics, including visual analysis based on a computational level, hardware implementation, and the design of new more advanced vision sensors. The last two sections of the book provide an overview of a few representative applications and current state of the art of the research in this area. This makes it a valuable book for graduate, Master, PhD students and also researchers in the field.

Rhythms of the Brain

Rhythms of the Brain
Author: G. Buzsáki
Publisher: Oxford University Press
Total Pages: 465
Release: 2011
Genre: Medical
ISBN: 0199828237

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Studies of mechanisms in the brain that allow complicated things to happen in a coordinated fashion have produced some of the most spectacular discoveries in neuroscience. This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. It takes a fresh look at the coevolution of structure and function in the mammalian brain, illustrating how self-emerged oscillatory timing is the brain's fundamental organizer of neuronal information. The small-world-like connectivity of the cerebral cortex allows for global computation on multiple spatial and temporal scales. The perpetual interactions among the multiple network oscillators keep cortical systems in a highly sensitive "metastable" state and provide energy-efficient synchronizing mechanisms via weak links. In a sequence of "cycles," György Buzsáki guides the reader from the physics of oscillations through neuronal assembly organization to complex cognitive processing and memory storage. His clear, fluid writing-accessible to any reader with some scientific knowledge-is supplemented by extensive footnotes and references that make it just as gratifying and instructive a read for the specialist. The coherent view of a single author who has been at the forefront of research in this exciting field, this volume is essential reading for anyone interested in our rapidly evolving understanding of the brain.

Epigenetics: Development and Disease

Epigenetics: Development and Disease
Author: Tapas Kumar Kundu
Publisher: Springer Science & Business Media
Total Pages: 698
Release: 2012-11-13
Genre: Medical
ISBN: 9400745257

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Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Molecular Biology of The Cell

Molecular Biology of The Cell
Author: Bruce Alberts
Publisher:
Total Pages: 0
Release: 2002
Genre: Cytology
ISBN: 9780815332183

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Extracellular Matrix in Development

Extracellular Matrix in Development
Author: Douglas W. DeSimone
Publisher: Springer Science & Business Media
Total Pages: 260
Release: 2013-03-15
Genre: Science
ISBN: 3642359353

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Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.