Markers of Endocrine Disruption in Fish
Author | : Rinus Bogers |
Publisher | : |
Total Pages | : 133 |
Release | : 2008 |
Genre | : |
ISBN | : 9789085852025 |
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Author | : Rinus Bogers |
Publisher | : |
Total Pages | : 133 |
Release | : 2008 |
Genre | : |
ISBN | : 9789085852025 |
Author | : David E. Kime |
Publisher | : Springer Science & Business Media |
Total Pages | : 402 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461549434 |
The last half-century has shown a dramatic increase in the standard of living of millions of people in Europe, North America and many parts of the Third World. This has, in many ways been brought about by scientific and technical developments which were initiated in the 1940s and 1950s. Promises were then made that nuclear energy would provide electricity so cheap that it would not need metering, pesticides would end malnutrition throughout the world and plastics and other synthetic chemicals would revolutionise our manufacturing industry and our way of life. Whilst some of these promises have been fulfilled, the problems of long-term health risks to humans and wildlife arising from the use, production and disposal of these products were either unknown or deliberately understated. Nuclear power is rendered economically unviable when the real cost of decommissioning and storage of waste for several millenia is included, and the effects on health of both humans and wildlife of early pest eradication programmes with organochlorine pesticides were well documented in Rachel Carson's "Silent Spring". Evidence of the effects of aerosols and refrigerants on depletion of the ozone layer has led to restriction on the use of CFCs, and there is now increasing evidence of climate change resulting from our profligate use of fossil fuels.
Author | : Ann Oliver Cheek |
Publisher | : |
Total Pages | : 10 |
Release | : 2004 |
Genre | : Anthracene |
ISBN | : |
Author | : Daniel Dietrich |
Publisher | : John Wiley & Sons |
Total Pages | : 272 |
Release | : 2009-07-31 |
Genre | : Technology & Engineering |
ISBN | : 9780470431788 |
Timely title assembling the combined knowledge of some of the leading authorities in the field of small fish reproduction - an important topic for risk assessment and registration of chemical, agricultural, and pharmaceutical compounds Provides guidance on the microscopic structure of living tissue and evaluation of the reproductive glands of small laboratory fish Includes state-of-the-art science along with sufficient anatomical and physiological background for understanding and interpreting test results Helps standardize the interpretation of results from aquatic bioassays and field observations, which will also clarify inconsistencies in the current scientific literature Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
Author | : |
Publisher | : |
Total Pages | : 88 |
Release | : 2012 |
Genre | : |
ISBN | : |
Endocrine disruptors are the substances which disrupt the normal functioning of the endocrine system by interfering with the variety of hormone-regulated physiological pathways and causing adverse health effects on the organism's physiology. They include plasticizers, pesticides, detergents and pharmaceuticals. These substances find their way into rivers and the ocean through sewage discharge and sediments at the bottom. Humans are also exposed to these toxic chemicals owing to water and fish consumption. The pelagic fish, which are bottom feeders, are at the highest risk of exposure to these harmful chemicals which settle in ocean sediments. As evidence of the threat of endocrine disrupting chemicals (EDCs) is mounting, there is a need to revise our research and improve our diagnostic efforts. With the advent of high-throughput sequencing technologies, we can now look at the complete transcriptional characterization of an organism. Sentinel fish, indicators of the environmental hazards, provide assessment for the endocrine disrupting chemicals present in the marine environment. For this thesis project, the RNA-Sequencing data of Sardine, Mackerel and Turbot were analyzed to obtain detailed snapshots of the transcriptome in both control (unpolluted) and impacted (polluted) fish. The RNA-Seq analysis of the altered expression patterns of the genes involved in important metabolic and physiological processes will provide a powerful tool for obtaining complete picture of the endocrine disruption in aquatic organisms.
Author | : P. V. Cline |
Publisher | : IWA Publishing |
Total Pages | : 277 |
Release | : 2003-01-01 |
Genre | : Science |
ISBN | : 1843396505 |
In recent years, concerns have been raised that low concentrations of chemicals may alter the normal functions of the endocrine system, resulting in potentially significant adverse effects on growth, reproduction, and/or development. For domestic wastewater discharges to surface water bodies, estrogenic activity of effluents has been suggested by chemical analysis, biomarkers, and /or in vitro assays. Chemical Measurements. Using sensitive analytical techniques, natural or synthetic hormones and chemicals that mimic estrogen, have been detected in some domestic wastewater effluents and associated watersheds at low concentrations. Biomarkers. Several studies have demonstrated physiological changes in fish that may be attributed to exposure to estrogenic compounds. These include the presence of vitellogenin protein in male fish and/or intersex conditions. In vitro assays. The Yeast Estrogen Screen (YES) has been used to characterize estrogenicity of effluents, influents, biosolids and surface waters. This two-year WERF project explored approaches to evaluate the potential for biomarker formation as a result of effluent exposures, and the subsequent relevance of the emerging assays and physiological measurements on potential adverse impacts to individuals or populations of fish in the receiving streams. The endocrine system is complex, and many factors can influence the physiological measurements, including methods, sex, age, reproductive status, seasonal and circadian rhythms, diet, temperature, etc. and produce transient changes in physiology but no significant effect on the individual.
Author | : David O. Norris |
Publisher | : Oxford University Press |
Total Pages | : 492 |
Release | : 2005-09-22 |
Genre | : Medical |
ISBN | : 019535026X |
This book addresses the biological effects of the reasonably large number of classes of compounds that have been recognized as endocrine disrupters. These compounds have been found to persist as pollutants in the environment, and have been blamed for causing developmental disorders and/or fertility problems in fish, amphibians, reptiles, birds, and possibly humans. This book presents the relevant fundamentals of the endocrine systems of animals and humans, the toxicology, developmental toxicology, ecology, and risk assessment methods, and lays out the current state of understanding for the whole field, organized by the classes of compounds that have been identified as endocrine disrupters.
Author | : Joakim Larsson |
Publisher | : |
Total Pages | : 160 |
Release | : 2000 |
Genre | : Endocrine toxicology |
ISBN | : |
Author | : Gitte I. Petersen |
Publisher | : Nordic Council of Ministers |
Total Pages | : 70 |
Release | : 2001 |
Genre | : Endocrine disrupting chemicals |
ISBN | : 9789289307215 |
Author | : Bram Versonnen |
Publisher | : |
Total Pages | : 116 |
Release | : 2003 |
Genre | : |
ISBN | : |