Life Out of Sequence

Life Out of Sequence
Author: Hallam Stevens
Publisher: University of Chicago Press
Total Pages: 303
Release: 2013-11-04
Genre: Science
ISBN: 022608034X
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Thirty years ago, the most likely place to find a biologist was standing at a laboratory bench, peering down a microscope, surrounded by flasks of chemicals and petri dishes full of bacteria. Today, you are just as likely to find him or her in a room that looks more like an office, poring over lines of code on computer screens. The use of computers in biology has radically transformed who biologists are, what they do, and how they understand life. In Life Out of Sequence, Hallam Stevens looks inside this new landscape of digital scientific work. Stevens chronicles the emergence of bioinformatics—the mode of working across and between biology, computing, mathematics, and statistics—from the 1960s to the present, seeking to understand how knowledge about life is made in and through virtual spaces. He shows how scientific data moves from living organisms into DNA sequencing machines, through software, and into databases, images, and scientific publications. What he reveals is a biology very different from the one of predigital days: a biology that includes not only biologists but also highly interdisciplinary teams of managers and workers; a biology that is more centered on DNA sequencing, but one that understands sequence in terms of dynamic cascades and highly interconnected networks. Life Out of Sequence thus offers the computational biology community welcome context for their own work while also giving the public a frontline perspective of what is going on in this rapidly changing field.

Life Out of Sequence

Life Out of Sequence
Author: Hallam Stevens
Publisher:
Total Pages: 294
Release: 2013-01-01
Genre: Computers
ISBN: 9781299850781
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Thirty years ago, the most likely place to find a biologist was standing at a laboratory bench, peering down a microscope, surrounded by flasks of chemicals and petri dishes full of bacteria. Today, you are just as likely to find him or her in a room that looks more like an office, poring over lines of code on computer screens. The use of computers in biology has radically transformed who biologists are, what they do, and how they understand life. In "Life Out of Sequence," Hallam Stevens looks inside this new landscape of digital scientific work. Stevens chronicles the emergence of bioinformatics the mode of working across and between biology, computing, mathematics, and statistics from the 1960s to the present, seeking to understand how knowledge about life is made in and through virtual spaces. He shows how scientific data moves from living organisms into DNA sequencing machines, through software, and into databases, images, and scientific publications. What he reveals is a biology very different from the one of predigital days: a biology that includes not only biologists but also highly interdisciplinary teams of managers and workers; a biology that is more centered on DNA sequencing, but one that understands sequence in terms of dynamic cascades and highly interconnected networks. "Life Out of Sequence" thus offers the computational biology community welcome context for their own work while also giving the public a frontline perspective of what is going on in this rapidly changing field. "

Biological Sequence Analysis

Biological Sequence Analysis
Author: Richard Durbin
Publisher: Cambridge University Press
Total Pages: 372
Release: 1998-04-23
Genre: Science
ISBN: 113945739X
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Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.

Sequence

Sequence
Author: Lori Andrews
Publisher: Macmillan
Total Pages: 340
Release: 2007-04-03
Genre: Fiction
ISBN: 9780312942458
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Geneticist Alexandra Blake uses her expertise to investigate a serial killer plaguing military bases across the country, but when an another murder hits close to home, Alex and her boyfriend, a Texas congressman, find their lives in danger.

Sequence Analysis in a Nutshell: A Guide to Tools

Sequence Analysis in a Nutshell: A Guide to Tools
Author: Scott Markel
Publisher: "O'Reilly Media, Inc."
Total Pages: 308
Release: 2003-01-27
Genre: Computers
ISBN: 9780596004941
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This work pulls together all of the vital information about the most commonly used databases, analytical tools, and tables used in sequence analysis.

A Passage Out of Sequence

A Passage Out of Sequence
Author: William F. Meininger
Publisher: AuthorHouse
Total Pages: 550
Release: 2007-11
Genre: Adventure stories
ISBN: 1434347281
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On a late November evening in 1936, Brad Harper, and three other airmail pilots, depart the Newark, NJ airport with contaminated fuel. Three of them crash, and two are killed. In early December 1940, Brad Harper, now a member of a jazz group, embarks on a steamship in Philadelphia for a two week working cruise, promising his family to be home for Christmas. When the ship docks in San Francisco, he unexpectedly encounters his uncle Jack, who is traveling to China to help operate a flying school. Jack tries to entice Brad into joining him, but Brad declines. However, while disembarking the ship, he meets a young doctor, Dorothy Lee Devereux (Dolly) and, like Jack, she is also traveling to the orient. It's love at first sight for both and Brad follows her to China. As luck would have it, both she and Jack are traveling to the same city. Arriving in Kunming, Brad's airmail experience puts him in good stead at the flying school and he soon becomes a flight instructor while Dolly works at Kunming General Hospital. With war looming, he is reluctantly drawn into Clare Chennault's Flying Tigers and becomes a squadron commander. As the war unfolds, he flies several missions against the Japanese, extracts vengeance when he murders a treacherous Chinese colonel, is involved in a midair collision, and faces courts-martial for a mercy killing. Soon after, he and Dolly marry, he is injured and they return home with an adopted daughter. Recovered, he is assigned to deliver aircraft to operational squadrons. On one such trip to England, he is Shanghaied into the Eight Air Force and detailed to a fighter squadron. On one mission he so distinguishes himself, he comes to the attention of General Doolittle, and is awarded a very high honor. Reluctant to return home, he convinces General Doolittle to allow him to remain in theater and is given positions of increasing responsibility. Meanwhile, his wife remains with his family in a small sea shore town to practice medicine. When the underworld attempts to take over the fishing industry, she is raped by gangsters. Before long an opportunity presents itself, and she extracts a brutal revenge. Discovered to have euthanized a patient, she finds others share her values. Returning home at war's end, circumstances have Brad departing the Newark, NJ airport in a P-51 fighter with no parachute. The plane, having been serviced from an old gas truck, has been contaminated.

The Judge of Ages

The Judge of Ages
Author: John C. Wright
Publisher: Macmillan
Total Pages: 381
Release: 2014-02-11
Genre: Fiction
ISBN: 0765329298
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The year is 10,515 AD. The Hyades Armada, traveling at near lightspeed, will reach Earth in just four centuries to assess humanity's value as slaves. For the last 8,000 years, two opposing factions have labored to meet the alien threat in very different ways. One of them is Ximen del Azarchel, immortal leader of the mutineers from the starship Hermetic and self-appointed Master of the World, who has allowed his followers to tamper continuously with the evolutionary destiny of Man, creating one bizarre race after another in an apparent search for a species the Hyades will find worthy of conquest. The other is Menelaus Montrose, the posthuman Judge of Ages, whose cryonic Tombs beneath the surface of Earth have preserved survivors from each epoch created by the Hermeticists. Montrose intends to thwart the alien invaders any way he can, and to remain alive long enough to be reunited with his bride Rania, who is on a seventy-millennia journey to confront the Hyades' masters, tens of thousands of light-years away. Now, with the countdown to the Hyades' arrival nearing its end, del Azarchel and Montrose square off for what is to be their final showdown for the fate of Earth, a battle of gunfire and cliometric calculus; powered armor and posthuman intelligence. Judge of Ages is the wildly inventive third volume in a series exploring future history and human evolution from John C. Wright.

Advances in Sequence Analysis: Theory, Method, Applications

Advances in Sequence Analysis: Theory, Method, Applications
Author: Philippe Blanchard
Publisher: Springer
Total Pages: 308
Release: 2014-07-02
Genre: Social Science
ISBN: 3319049690
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This book gives a general view of sequence analysis, the statistical study of successions of states or events. It includes innovative contributions on life course studies, transitions into and out of employment, contemporaneous and historical careers, and political trajectories. The approach presented in this book is now central to the life-course perspective and the study of social processes more generally. This volume promotes the dialogue between approaches to sequence analysis that developed separately, within traditions contrasted in space and disciplines. It includes the latest developments in sequential concepts, coding, atypical datasets and time patterns, optimal matching and alternative algorithms, survey optimization, and visualization. Field studies include original sequential material related to parenting in 19th-century Belgium, higher education and work in Finland and Italy, family formation before and after German reunification, French Jews persecuted in occupied France, long-term trends in electoral participation, and regime democratization. Overall the book reassesses the classical uses of sequences and it promotes new ways of collecting, formatting, representing and processing them. The introduction provides basic sequential concepts and tools, as well as a history of the method. Chapters are presented in a way that is both accessible to the beginner and informative to the expert.

Bioinformatics

Bioinformatics
Author: Hamid D. Ismail
Publisher: CRC Press
Total Pages: 466
Release: 2022-03-23
Genre: Science
ISBN: 1000519074
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Bioinformatics: A Practical Guide to NCBI Databases and Sequence Alignments provides the basics of bioinformatics and in-depth coverage of NCBI databases, sequence alignment, and NCBI Sequence Local Alignment Search Tool (BLAST). As bioinformatics has become essential for life sciences, the book has been written specifically to address the need of a large audience including undergraduates, graduates, researchers, healthcare professionals, and bioinformatics professors who need to use the NCBI databases, retrieve data from them, and use BLAST to find evolutionarily related sequences, sequence annotation, construction of phylogenetic tree, and the conservative domain of a protein, to name just a few. Technical details of alignment algorithms are explained with a minimum use of mathematical formulas and with graphical illustrations. Key Features Provides readers with the most-used bioinformatics knowledge of bioinformatics databases and alignments including both theory and application via illustrations and worked examples. Discusses the use of Windows Command Prompt, Linux shell, R, and Python for both Entrez databases and BLAST. The companion website contains tutorials, R and Python codes, instructor materials including slides, exercises, and problems for students. This is the ideal textbook for bioinformatics courses taken by students of life sciences and for researchers wishing to develop their knowledge of bioinformatics to facilitate their own research.

The Sequence to Success

The Sequence to Success
Author: Samuel R. Chand
Publisher: Whitaker House
Total Pages: 127
Release: 2020-03-10
Genre: Business & Economics
ISBN: 1641233923
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Every one of us gets anywhere in life due to three things: someone observes us, forms an opinion about us, and decides to give us an opportunity…or not. Likewise, we do the same thing with others. People have played this essential role in our lives, and we play it in the lives of those around us—and no matter how skilled we’ve become, we can play it even better. The sequence applies in business, the church, marriages, parenting, and friendships. We often assess others in the blink of an eye. We instinctively notice the look on someone’s face, the tone of voice, or the body language that’s consistent or different from the words being spoken. We react to our observation, but we seldom stop to analyze before we respond—it just happens, and it happens immediately: we observe and have an opinion, and based on what we’ve determined in that second, we either give the person an opportunity to engage with us or we close the door and remain guarded. The Sequence to Success: Three O’s That Will Take You Anywhere in Life is a leadership book, but it’s not limited to corporate presidents, CEOs, or lead pastors; it’s for everyone who has a position of influence in another person’s life—and that includes all of us. In this book, Sam Chand brings our subconscious assumptions into the light. With more insight and confidence, you’ll make better decisions to advance the people around you…or perhaps show them the door. These principles also help you become more conscious that people are observing you and forming opinions about you that will open or close doors of opportunity.