Innovative 3D models for Understanding Mechanisms underlying Lung Diseases: Powerful Tools for Translational Research

Innovative 3D models for Understanding Mechanisms underlying Lung Diseases: Powerful Tools for Translational Research
Author: Janette K. Burgess
Publisher: Frontiers Media SA
Total Pages: 180
Release: 2024-02-05
Genre: Science
ISBN: 2832544177
GET BOOK

Download Innovative 3D models for Understanding Mechanisms underlying Lung Diseases: Powerful Tools for Translational Research Book in PDF, Epub and Kindle

The mechanisms underlying acute and chronic lung diseases are complex, reflecting the interplay between multiple cell types, their microenvironment and exogenous challenges. While traditional in vitro cell culture approaches have been instrumental in advancing our knowledge of cellular signalling and function, they typically lack the cell-cell and cell-matrix interactions that define the niche in which lung cell and tissue functions emerge. Implementing in vivo and ex vivo three-dimensional (3D) models more realistically mimicking the in vivo cell-extracellular matrix (ECM) crosstalk should facilitate a considerable leap towards better understanding lung diseases and thus in investigating new pharmacological tools. We are experiencing a revolution in our understanding of the cell types that deposit and remodel ECM in the lung, the dynamic spatial composition of the ECM and cell-cell interactions during disease, and the influence of ECM and cell-derived cues on lung cell biology. In concert, the ex vivo and in vitro models that are being used to examine the role of the 3D microenvironment of the cell in the lung are rapidly developing. The European Respiratory Society has partnered with Frontiers in Pharmacology to launch this research topic in conjunction with the ERS Research Seminar “Innovative 3D models for understanding mechanisms underlying lung diseases: powerful tools for translational research”.

Innovative In Vitro Models for the Study of Lung Diseases

Innovative In Vitro Models for the Study of Lung Diseases
Author: Isotta Chimenti
Publisher:
Total Pages: 0
Release: 2022
Genre: Medical
ISBN:
GET BOOK

Download Innovative In Vitro Models for the Study of Lung Diseases Book in PDF, Epub and Kindle

Basic and translational research on lung biology and pathology can greatly benefit from the development of 3D in vitro models with physiological relevance. Lung organoids and lungs-on-chip allow the creation of different kinds of in vitro microenvironments, that can be useful for the elucidation of novel pathogenetic pathways, for example concerning tissue fibrosis in chronic diseases. Moreover, they represent important translational models for the identification of novel therapeutic targets, and for preliminary testing of new drugs. In this chapter, we provide a selected overview of recent studies on innovative 3D in vitro models that have enhanced our knowledge on chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), particularly concerning oxidative stress and pro-fibrotic pathogenetic mechanisms. Despite several limitations, these complex models must be considered as complementary in all respects to in vivo studies on animal models and clinical research.

3D Lung Models for Regenerating Lung Tissue

3D Lung Models for Regenerating Lung Tissue
Author: Gunilla Westergren-Thorsson
Publisher: Elsevier
Total Pages: 260
Release: 2022-08-12
Genre: Medical
ISBN: 0323908713
GET BOOK

Download 3D Lung Models for Regenerating Lung Tissue Book in PDF, Epub and Kindle

3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current state of art 3D lung models and novel techniques that can be used to regenerate lung tissue. Written by experts in the field, readers can expect to learn more about 3D lung models, novel techniques including bioprinting and advanced imaging techniques, as well as important knowledge about the complexity of the lung and its extracellular matrix composition. Structured into 15 different chapters, the book spans from the original 2D cell culture model on plastic, to advanced 3D lung models such as using human extracellular matrix protein. In addition, the last chapters cover new techniques including 3D printing, bioprinting, and artificial intelligence that can be used to drive the field forward and some future perspectives. This highly topical book with chapters on everything from the complexity of the lung and its microenvironment to cutting-edge 3D lung models, represents an exciting body of work that can be used by researchers during study design, grant writing, as teaching material, or to stay updated with the progression of the field. A comprehensive summary of advanced 3D lung models written by the experts in the respiratory field Explore novel techniques that can be used to evaluate and improve 3D lung models, including techniques such as 3D printing, bioprinting, and artificial intelligence Explains what extracellular matrix is, the complexity of the lung microenvironment, and why this knowledge is important for creating a functional bioartificial lung

The Lung

The Lung
Author: Ahmed El-Hashash
Publisher: Elsevier
Total Pages: 174
Release: 2021-06-15
Genre: Medical
ISBN: 0128212063
GET BOOK

Download The Lung Book in PDF, Epub and Kindle

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world. Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseases Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lung Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the lung

Targeting Cellular Signalling Pathways in Lung Diseases

Targeting Cellular Signalling Pathways in Lung Diseases
Author: Kamal Dua
Publisher: Springer
Total Pages: 0
Release: 2022-07-04
Genre: Medical
ISBN: 9789813368293
GET BOOK

Download Targeting Cellular Signalling Pathways in Lung Diseases Book in PDF, Epub and Kindle

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Engineering Translational Models of Lung Homeostasis and Disease

Engineering Translational Models of Lung Homeostasis and Disease
Author: Chelsea M. Magin
Publisher:
Total Pages: 0
Release: 2023
Genre:
ISBN: 9783031266270
GET BOOK

Download Engineering Translational Models of Lung Homeostasis and Disease Book in PDF, Epub and Kindle

Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

CRC Handbook of Animal Models of Pulmonary Disease

CRC Handbook of Animal Models of Pulmonary Disease
Author: Jerome Owen Cantor
Publisher: CRC Press
Total Pages: 256
Release: 1989-10-31
Genre: Medical
ISBN: 9780849329784
GET BOOK

Download CRC Handbook of Animal Models of Pulmonary Disease Book in PDF, Epub and Kindle

This two-volume handbook provides important information concerning the development, implementation, evaluation, uses, advantages, and limitations of a wide variety of animal model of pulmonary disease. While the work focuses on stepwise procedures for inducing and quantifying disease, additional emphasis is placed on each model's relationship to human counterparts and on comparisons with similar models of injury. Thus, even the novice researcher will be able to more sharply define a particular research question, find suitable animal models for study, gain access to specialized techniques, and evaluate results within the context of an up-to-date body of information about related forms of lung diseases.

Cell Interaction

Cell Interaction
Author: Bhawana Singh
Publisher: BoD – Books on Demand
Total Pages: 230
Release: 2021-04-07
Genre: Medical
ISBN: 183968416X
GET BOOK

Download Cell Interaction Book in PDF, Epub and Kindle

This book discusses contemporary ideas on different molecular and immunological aspects of diseases. Different signaling mediators drive the production of messenger molecules that mediate their action, leading to the elicitation/suppression of immune responses. It provides a balanced approach to the study of different molecular phenomena that eventually drive infection outcomes and that can be manipulated for therapeutic benefits.

Lung Development

Lung Development
Author: Claude Gaultier
Publisher: Springer
Total Pages: 464
Release: 2013-05-27
Genre: Medical
ISBN: 1461475376
GET BOOK

Download Lung Development Book in PDF, Epub and Kindle

Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.

Lung Stem Cells in Development, Health and Disease

Lung Stem Cells in Development, Health and Disease
Author: Nikolic, Marko Z.
Publisher: European Respiratory Society
Total Pages: 395
Release: 2021-04-01
Genre: Medical
ISBN: 1849841349
GET BOOK

Download Lung Stem Cells in Development, Health and Disease Book in PDF, Epub and Kindle

Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science