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| Author | : R. Christopher Pierce |
| Publisher | : |
| Total Pages | : 236 |
| Release | : 1993 |
| Genre | : |
| ISBN | : |
| Author | : |
| Publisher | : |
| Total Pages | : 758 |
| Release | : 1994 |
| Genre | : Dissertations, Academic |
| ISBN | : |
| Author | : |
| Publisher | : |
| Total Pages | : 704 |
| Release | : 1993 |
| Genre | : Dissertation abstracts |
| ISBN | : |
| Author | : Udo Rüb |
| Publisher | : Springer |
| Total Pages | : 154 |
| Release | : 2015-09-29 |
| Genre | : Medical |
| ISBN | : 331919285X |
This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
| Author | : |
| Publisher | : |
| Total Pages | : 1160 |
| Release | : 1985 |
| Genre | : Medicine |
| ISBN | : |
| Author | : Gordon M. Shepherd |
| Publisher | : Oxford University Press |
| Total Pages | : 736 |
| Release | : 2004 |
| Genre | : Medical |
| ISBN | : 019515956X |
This is a thorough revision of the standard text on local circuits in the different regions of the brain. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods.
| Author | : Minoru Kimura |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 222 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 4431685472 |
In this volume, which is based on the proceedings of the international symposium "Functional Linkages Between the Cerebral Cortex and Basal Ganglia in the Control of Voluntary Movement", held December 1993 in Osaka, Japan, the world's leading neuroscientists present the most up-to-date findings of current research on cortico-basal ganglia relations. Topics addressed in this book include the structure and function of basal ganglia cells and systems, the organization of thalamo-cortical systems, the frontal cortex, and clinical applications of ongoing studies. Of particular interest is the analysis of models of motor learning and functional schemes of cortico-basal ganglia and striatal circuitry. The valuable new insights this interdisciplinary work provides will benefit researchers and students in fields such as neurobiology, behavioral neurophysiology, neurochemistry, and neuropharmacology.
| Author | : |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 62 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642738974 |
As in other volumes in the series, this newest volume conveys up-to-date knowledge in a clear and straightforward manner. It begins with a survey of the neurobiological functions of the brain, with the emphasis on Parkinson's disease. This is followed by a presentation of the role of dopamine in the regulation of human anterior pituitary function. The final two chapters concentrate on the dopamine receptors: first, the binding sites are characterized and the biochemical and physiological consequences of dopamine-receptor stimulation are discussed and, finally, there is a report on the topology of a dopamine-receptor model that can account comprehensively for agonists and antagonists.
| Author | : Roy Webster |
| Publisher | : John Wiley & Sons |
| Total Pages | : 550 |
| Release | : 2001-11-28 |
| Genre | : Medical |
| ISBN | : 9780471978190 |
Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.
| Author | : Sandeep Mittal |
| Publisher | : Springer |
| Total Pages | : 422 |
| Release | : 2015-11-18 |
| Genre | : Science |
| ISBN | : 3319118706 |
Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.
