The Department of Energy's Nevada Test Site (NTS) lies in the southern part of the Great Basin Section of the Basin and Range Physiographic Province. This report addresses the geological setting of the NTS in the context of the current waste isolation policy. The intent is to provide a synthesis of geological conditions at the NTS and nearby areas so that a general background of information is available for assessing the possible role of geology in providing protections for humans from buried radioactive wastes. The NTS is characterized by alluvium-filled, topographically closed valleys surrounded by ranges composed of Paleozoic sedimentary rocks and Tertiary volcanic tuffs and lavas. The Paleozoic rocks are a miogeosynclinal sequence of about 13,000 ft of pre-Cambrian to Cambrian clastic deposits (predominantly quartzites) overlain by about 14,000 ft of Cambrian through Devonian carbonates, 8000 ft of Mississippian argillites and quartzites, and 3000 ft of Pennsylvanian to Permian limestones. Tertiary volcanic rocks are predominantly silicic composition and were extruded from numerous eruptive centers during Miocene and Pliocene epochs. Within eruptive caldera depressions, volcanic deposits accumulated to perhaps 10,000 ft in total thickness, thinning to extinction outward from the calderas. Extrusion of minor amounts of basalts accompanied Pliocene and Pleistocene filling of structural basins with detritus from the ranges. Regional compressional and extensional structures as well as local volcanic structures occur in the NTS region. Normal extensional faulting coincided with the outbreak of volcanism during the Miocene and was superimposed on existing Mesozoic structures. Continued extensional deformation may be occurring at the present time.