Dna Topoisomerases In Cancer Chemotherapy
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Author | : Yves Pommier |
Publisher | : Springer Science & Business Media |
Total Pages | : 443 |
Release | : 2011-09-21 |
Genre | : Medical |
ISBN | : 1461403235 |
Download DNA Topoisomerases and Cancer Book in PDF, Epub and Kindle
DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.
Author | : Toshiwo Andoh |
Publisher | : Springer Science & Business Media |
Total Pages | : 208 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461501415 |
Download DNA Topoisomerases in Cancer Therapy Book in PDF, Epub and Kindle
In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.
Author | : |
Publisher | : |
Total Pages | : 162 |
Release | : 1987 |
Genre | : Antineoplastic agents |
ISBN | : |
Download First Conference on DNA Topoisomerases in Cancer Chemotherapy Book in PDF, Epub and Kindle
Author | : |
Publisher | : |
Total Pages | : 456 |
Release | : 2011-09-21 |
Genre | : |
ISBN | : 9781461403241 |
Download DNA Topoisomerases and Cancer Book in PDF, Epub and Kindle
Author | : Milan Potmesil |
Publisher | : Oxford University Press, USA |
Total Pages | : 364 |
Release | : 1991 |
Genre | : Medical |
ISBN | : |
Download DNA Topoisomerases in Cancer Book in PDF, Epub and Kindle
DNA Topoisomerases are a unique class of enzymes that are responsible for the control and modification of DNA topology (tertiary structure); one example of their function is the transformation of chromosomes from a supercoiled condensed state to uncoiled strands and vice versa. They are of interest both for their intrinsic role in cell biology (i.e. control of cell division) and also because some anticancer drugs, such as camptothecin, act by inhibiting their action.
Author | : Toshiwo Andoh |
Publisher | : CRC Press |
Total Pages | : 400 |
Release | : 1992-10-26 |
Genre | : Medical |
ISBN | : 9780849349706 |
Download Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy Book in PDF, Epub and Kindle
Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy is based on conference proceedings from the International Symposium on DNA Topoisomerases in Chemotherapy, held in Nagoya, Japan, in November 1991. The book opens with a discussion of the structural and functional properties of various types of DNA topoisomerases identified in prokaryotes and eukaryotes, in addition to their roles as cellular targets of anticancer and antimicrobial agents. Other topics addressed include the genetics and biology of DNA topoisomerases, inhibitors of microbial DNA topoisomerases and drug resistance, inhibitors of mammalian DNA topoisomerases and drug resistance, and preclinical and clinical studies of DNA topoisomerase inhibitors. Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of topoisomerases. It will be invaluable for oncologists, molecular biologists, cellular biologists, geneticists, biochemists, and pharmaceutical researchers.
Author | : Stella Margaret Davies |
Publisher | : |
Total Pages | : 144 |
Release | : 1989 |
Genre | : |
ISBN | : |
Download DNA Topoisomerases in Cancer Chemotherapy Book in PDF, Epub and Kindle
Author | : Milan Potmesil |
Publisher | : |
Total Pages | : 149 |
Release | : 1987 |
Genre | : |
ISBN | : |
Download DNA Topoisomerases in Cancer Chemotherapy Book in PDF, Epub and Kindle
Author | : |
Publisher | : |
Total Pages | : |
Release | : 1987 |
Genre | : |
ISBN | : |
Download First Conference on DNA Topoisomerases in Cancer Chemotherapy Book in PDF, Epub and Kindle
Author | : Robert F. Ozols |
Publisher | : Springer Science & Business Media |
Total Pages | : 314 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461538726 |
Download Molecular and Clinical Advances in Anticancer Drug Resistance Book in PDF, Epub and Kindle
The importance of drug resistance in cancer chemotherapy cannot be over stated. The 500,000 patients who die every year from cancer in the United States have, in most cases, been treated with chemotherapy. Many of these patients responded initially to chemotherapy, but death resulted from the development of drug-resistant tumors. In the first volume in the series. Drug Resistance in Chemotherapy the results of comprehensive laboratory studies aimed at understanding the mechanisms for resistance to individual agents and to the development of broad cross-resistance were described. In the past 2 years there has been substantial progress in understanding the molecular biology associated with these mechanisms of drug resistance. For the first time we are starting to understand which mechanisms are playing an im portant role in human tumors, and even more importantly, clinical trials have recently been initiated in an effort to reverse specific forms of drug resistance. The purpose of this volume is to describe the new advances, both at the molecular level and in the clinic regarding mechanisms of drug resistance and potential ways this resistance can be circumvented. This volume is focused upon mechanisms of resistance associated with two major classes of anticancer drugs: alkylating agents (including cisplatin) and the natural products (e. g. , adriamycin and vinblastine). The first section of the book describes new insights into the genetic mechanisms associated with drug resistance.