Diagnostic Prognostic And Therapeutic Role Of Micrornas In Head And Neck Cancer
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| Author | : Ashok Kumar |
| Publisher | : Elsevier |
| Total Pages | : 363 |
| Release | : 2024-07-25 |
| Genre | : Science |
| ISBN | : 0443159696 |
Download Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer Book in PDF, Epub and Kindle
Early diagnosis of HNSCC can cause improved treatment, treatment response rates and reduction in mortality rates. Recently, miRNA-based diagnostics and therapeutics have gained considerable attention among the scientific community. MiRNAs are known to have great potential as biomarkers for early diagnosis, prediction, and prognosis of HNSCC, and play a role in development of targeted gene therapy.Diagnostic, Prognostic and Therapeutic Role of MicroRNAs in Head and Neck Cancer provides detailed information on various miRNA-based approaches for diagnosis, prognosis, and treatment of HNSCC. It encompasses various miRNA-based point of care diagnostics and drug delivery systems for HNSCC along with the information on the clinical trials of miRNAs for improved clinical outcomes in HNSCC patients. The book provides a comprehensive overview of currently available miRNAs associated with HNSCC and their extensive application for early diagnosis, prognosis, and treatment. This book will help scientists and clinicians to win the battle against HNSCC. Covers the role of the tumor microenvironment in head and neck cancer Provides information on oncogenic and tumor suppressor miRNAs dysregulated in HNSCC patients Elucidates the role of miRNAs in metastasis, recurrence, and chemoresistance in HNSCC Includes the current state-of-art in miRNA-based clinical trials for head
| Author | : César López-Camarillo |
| Publisher | : CRC Press |
| Total Pages | : 428 |
| Release | : 2013-02-22 |
| Genre | : Science |
| ISBN | : 1466576766 |
Download MicroRNAs in Cancer Book in PDF, Epub and Kindle
MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from bench to bedside applications and are written by an international team of renowned experts in the field.
| Author | : DKV Prasad |
| Publisher | : Springer Nature |
| Total Pages | : 183 |
| Release | : 2022-06-07 |
| Genre | : Medical |
| ISBN | : 981169186X |
Download Role of MicroRNAs in Cancers Book in PDF, Epub and Kindle
This book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.
| Author | : Sadegh Babashah |
| Publisher | : Springer |
| Total Pages | : 449 |
| Release | : 2014-07-08 |
| Genre | : Medical |
| ISBN | : 3319037250 |
Download MicroRNAs: Key Regulators of Oncogenesis Book in PDF, Epub and Kindle
Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.
| Author | : William C.S. Cho |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 553 |
| Release | : 2011-01-25 |
| Genre | : Medical |
| ISBN | : 9400702981 |
Download MicroRNAs in Cancer Translational Research Book in PDF, Epub and Kindle
MicroRNA (miRNA) is a cutting-edge topic in the scientific and medical fields. This is a timely and specialized book focusing on the current understanding of miRNAs and the potential for their application in cancer diagnosis, prognosis, and therapeutic targets. It also provides discussion of the lessons learned from translational miRNA studies and exploration of the next steps required to advance this field. The unique book comprises 22 in-depth chapters by gathering unparalleled topics of interest in miRNAs by international team of world-renowned experts in the field. The first fifteen chapters provide comprehensive and expert perspectives on the most common cancers from bench to bedside applications, there is no current book structured in this cancer-oriented way. The next seven chapters providing thorough overviews of miRNAs and cancer stem cells; miRNAs in cancer invasion and metastasis; miRNAs in predicting radiotherapy and chemotherapy response; as well as expounding the role of miRNA in anti-cancer drug resistance and as blood-based cancer biomarkers. Furthermore, this book explicates the interplay of miRNAs in cancer metabolism and an update on the pioneering RNAi-based treatment approaches is also presented. This specialized book will contribute great to the scientific and medical community by providing the up-to-date discoveries of miRNAs and their important roles in cancer translational research.
| Author | : Shree Ram Singh |
| Publisher | : Springer Science & Business |
| Total Pages | : 410 |
| Release | : 2014-04-21 |
| Genre | : Medical |
| ISBN | : 1489980652 |
Download MicroRNA in Development and in the Progression of Cancer Book in PDF, Epub and Kindle
miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
| Author | : Takahiro Ochiya |
| Publisher | : |
| Total Pages | : |
| Release | : 2018 |
| Genre | : |
| ISBN | : 9783038972532 |
Download MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers Book in PDF, Epub and Kindle
MicroRNAs (miRNAs) constitute a large family of small, approximately 20-22-nucleotide, non-coding RNAs that are involved in gene regulation, mainly at the post-transcriptional level. Multiple lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are involved in the onset of many diseases, including cancer. In various types of cancer, miRNAs play important roles in tumor initiation and development. Recently, miRNAs have been demonstrated to also be secreted via small endosome-derived vesicles called exosomes-which are derived from multiple cell types-including immunocytes and cancer cells. Exosomal miRNAs exert important functions in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers. This Special Issue of the Journal of Clinical Medicine will cover the following important aspects of miRNA functions in cancer biology: Biosynthesis of miRNA and its roles in gene regulation; Roles of miRNA in cancer biology, including 1) Roles of miRNA in tumor initiation and development, 2) Roles of miRNA in drug resistance, 3) Roles of miRNA in metastasis; Therapeutic potential of miRNAs for cancer therapy; Roles of circulating miRNAs in cancer development; Expression levels/profiles of body fluid miRNAs for cancer diagnosis, prognosis, and therapeutic responses; Novel and efficient miRNA delivery methods and their applications in cancer therapy.
| Author | : Philip V Peplow |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 500 |
| Release | : 2019-05-21 |
| Genre | : Medical |
| ISBN | : 1788013948 |
Download MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets Book in PDF, Epub and Kindle
From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.
| Author | : Alessandra Pulliero |
| Publisher | : Mdpi AG |
| Total Pages | : 280 |
| Release | : 2022-05-09 |
| Genre | : |
| ISBN | : 9783036538068 |
Download Role of MicroRNA in Cancer Development and Treatment Book in PDF, Epub and Kindle
Many researchers around the world have demonstrated that the expression of miRNAs is dysregulated in different tumors. Such dysregulation is caused by multiple mechanisms, and exposure to different carcinogens causes dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. Cancer cells with abnormal miRNA expression evolve the capability to sustain proliferative signaling, evade growth suppressors, resist cell death, activate invasion and metastasis, and induce angiogenesis. Genome-wide profiling demonstrates that miRNA expression signatures are associated with tumor type, tumor grade and clinical outcomes, so miRNAs could be potential candidates for diagnostic biomarkers, prognostic biomarkers, therapeutic targets and preventive screening programs. Although miRNAs have multiple targets, their function in tumorigenesis is due to their regulation of a few specific targets. After the first detection of altered miRNA in leukemia, microRNAs have been demonstrated to be constantly altered in all cancer. More recently, microRNA has been shown to be altered by exposure to environmental carcinogens, thus driving the whole process of carcinogenesis. Our aim is to provide a rigorous peer review and publish cutting-edge research on the role of microRNA in cancer prevention therapy to educate and inspire the scientific community worldwide.
| Author | : Susan Costantini Alfredo Budillon |
| Publisher | : MDPI |
| Total Pages | : 294 |
| Release | : 2021-02-12 |
| Genre | : Medical |
| ISBN | : 3039439774 |
Download New Prognostic and Predictive Markers in Cancer Progression Book in PDF, Epub and Kindle
Biomarkers are of critical medical importance for oncologists, allowing them to predict and detect disease and to determine the best course of action for cancer patient care. Prognostic markers are used to evaluate a patient’s outcome and cancer recurrence probability after initial interventions such as surgery or drug treatments and, hence, to select follow-up and further treatment strategies. On the other hand, predictive markers are increasingly being used to evaluate the probability of benefit from clinical intervention(s), driving personalized medicine. Evolving technologies and the increasing availability of “multiomics” data are leading to the selection of numerous potential biomarkers, based on DNA, RNA, miRNA, protein, and metabolic alterations within cancer cells or tumor microenvironment, that may be combined with clinical and pathological data to greatly improve the prediction of both cancer progression and therapeutic treatment responses. However, in recent years, few biomarkers have progressed from discovery to become validated tools to be used in clinical practice. This Special Issue comprises eight review articles and five original studies on novel potential prognostic and predictive markers for different cancer types.
