Serotonin Receptors in Neurobiology

Serotonin Receptors in Neurobiology
Author: Amitabha Chattopadhyay
Publisher: CRC Press
Total Pages: 230
Release: 2007-05-17
Genre: Medical
ISBN: 1420005758

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A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l

Cyclic AMP

Cyclic AMP
Author: G Robison
Publisher: Elsevier
Total Pages: 544
Release: 2012-12-02
Genre: Science
ISBN: 0323146481

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Cyclic AMP provides information pertinent to cyclic adenosine 3',5'-monophosphate (AMP), a regulatory agent that controls the rate of a number of cellular processes. This book discusses the heat-stable factor mediating the action of glucagon and epinephrine on the activation of liver phosphorylase. Organized into 12 chapters, this book starts with an overview of the biological role of cyclic AMP, which is extended from a relatively simple role in liver glycogenolysis to a significant regulatory agent in most mammalian tissues. This text then discusses the development that led to the discovery of the heat-stable factor from investigations with cyclic nucleotides. Other chapters explore the chemical agents, which are released from one group of cells and travel via the bloodstream to affect one or more different groups of cells. The final chapter discusses the role of cyclic AMP to mammalian physiology, with emphasis on the many possible defects that may lead to human disease. This book is a valuable resource for graduate students and clinical investigators involved in biological and biomedical sciences.

C++ AMP

C++ AMP
Author: Ade Miller
Publisher: Pearson Education
Total Pages: 467
Release: 2012-09-15
Genre: Computers
ISBN: 0735668191

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Capitalize on the faster GPU processors in today’s computers with the C++ AMP code library—and bring massive parallelism to your project. With this practical book, experienced C++ developers will learn parallel programming fundamentals with C++ AMP through detailed examples, code snippets, and case studies. Learn the advantages of parallelism and get best practices for harnessing this technology in your applications. Discover how to: Gain greater code performance using graphics processing units (GPUs) Choose accelerators that enable you to write code for GPUs Apply thread tiles, tile barriers, and tile static memory Debug C++ AMP code with Microsoft Visual Studio Use profiling tools to track the performance of your code

Chemosensory Transduction

Chemosensory Transduction
Author: Frank Zufall
Publisher: Academic Press
Total Pages: 432
Release: 2016-02-18
Genre: Science
ISBN: 0128017864

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Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals. Provides a comprehensive overview for all chemosensory transduction mechanisms Valuable for academics focused on sensory biology, neurobiology, and chemosensory transduction, as well as industry researchers in new flavor, fragrance, and food testing Edited by leading experts in the field of olfactory transduction Focuses on mammals, but lower vertebrates and invertebrate model systems are also included

Cystogenesis

Cystogenesis
Author: Jong Hoon Park
Publisher: Springer
Total Pages: 128
Release: 2016-10-12
Genre: Medical
ISBN: 9811020418

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Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Cyclic AMP, Cell Growth, and the Immune Response

Cyclic AMP, Cell Growth, and the Immune Response
Author: W. Braun
Publisher: Springer Science & Business Media
Total Pages: 430
Release: 2013-11-09
Genre: Medical
ISBN: 3642860265

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The brilliant research of Dr. Earl Sutherland and his colleagues has had a broad impact on many areas of biology. Among the fields in fluenced rather late by the insights arising from this work were im munology and oncology. Although research relating cyclic AMP metabol ism to the development and manifestations of the immune response and the control of mammalian cell growth is relatively recent, the growth of knowledge in these areas has been rapid and there is already a considera ble amount of empirical information. This conference provided an oppor tunity to collate and begin to interpret that information. A deliberate at tempt was made to bring together investigators nominally involved in im munology, biochemistry, pharmacology, or cellular biology for in many instances parallel observations are being obtained in these fields. For ex ample, the immunologist studying the transformation of lymphocytes by antigens or mitogens is carrying out experiments that are very close to those of the biologist studying the growth of cells in culture; in both cases, the phenomena they observe are modulated by changes in the in tracellular level of cyclic nucleotides. Many other examples of closely analogous experiments in different fields could be cited, but perhaps the point is clear.

Pancreatic Beta Cell in Health and Disease

Pancreatic Beta Cell in Health and Disease
Author: Susumu Seino
Publisher: Springer Science & Business Media
Total Pages: 475
Release: 2008-04-08
Genre: Science
ISBN: 4431754520

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The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.

Cyclic AMP

Cyclic AMP
Author: George I Drummond
Publisher:
Total Pages: 872
Release: 1975
Genre: Cyclic adenylic acid
ISBN:

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