Antivirals for Pandemic Influenza

Antivirals for Pandemic Influenza
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 132
Release: 2008-07-11
Genre: Medical
ISBN: 0309118662

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Planning for an influenza pandemic, whether it occurs in the near or distant future, will need to take into account many constantly evolving factors. The Institute of Medicine (IOM) Committee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic was asked by the Department of Health and Human Services, (DHHS) to consider best practices and policies for providing antiviral treatment and prophylaxis during a pandemic event. The committee's report, entitled Antivirals for Pandemic Influenza: Guidance on Developing a Distribution and Dispensing Program, calls for a national and public process of creating an ethical framework for antiviral use within the context of uncertainty and scarcity. It is unclear whether antivirals will work against a pandemic strain as well as they work against seasonal influenza. Also, government stockpiles may not be sufficient for all possible uses in part because antivirals are costly and public health agencies must invest in other important activities, including other medical resources for pandemic influenza. Furthermore, the report identifies the lack of a science-based advisory body to guide decision making during the pandemic, including guidance on all dimensions of antiviral dispensing (for example, prioritization, drug safety, and antiviral resistance). The report also acknowledges the need for diverse methods and sites of dispensing, and discusses their advantages and disadvantages.

Public Engagement on Facilitating Access to Antiviral Medications and Information in an Influenza Pandemic

Public Engagement on Facilitating Access to Antiviral Medications and Information in an Influenza Pandemic
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 56
Release: 2012-07-20
Genre: Medical
ISBN: 0309256976

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Influenza pandemics overwhelm health care systems with thousands or hundreds of thousands of sick patients, as well as those worried they may be sick. In order to ensure a successful response to the patient swell caused by a pandemic, robust planning is essential to prepare for challenges public health officials may face. This includes the need to quickly distribute and dispense antiviral medications that can reduce the severity and duration of disease to large numbers of people. In response to a request from the Centers for Disease Control, the Institute of Medicine's Forum on Medical and Public Health Preparedness for Catastrophic Events held a series of workshops that explored the public's perception of how to facilitate access to antiviral medications and treatment during an influenza pandemic. To help inform potential strategies still in the development stages at the CDC, workshops were held in Fort Benton, Montana; Chattanooga, Tennessee; and Los Angeles, California during February and March 2012 to consider the usefulness of several alternative strategies of delivering antiviral medication to the public. Participants considered how the normal systems for prescribing and dispensing antiviral medications could be adjusted to ensure that the public has quick, safe, and equitable access to both potentially life-saving drugs and information about the pandemic and treatment options. This document summarizes the workshops.

Influenza Pandemic

Influenza Pandemic
Author: Marcia Crosse
Publisher: DIANE Publishing
Total Pages: 76
Release: 2008-11
Genre: Health & Fitness
ISBN: 1437900062

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Pandemic influenza poses a threat to public health at a time when the U.N.¿s World Health Organization has said that infectious diseases are spreading faster than at any time in history. The last major influenza pandemic occurred from 1918 to 1919. Estimates of deaths worldwide if a similar pandemic were to occur have ranged between 30 million and 384 million people. Individual countries and international organizations have developed and begun to implement a strategy for forestalling the onset of a pandemic. Antivirals and vaccines may help do so. This report examines: (1) constraints upon the use of antivirals and vaccines to forestall a pandemic; and (2) efforts under way to overcome these constraints. Charts and tables.

Public Engagement on Facilitating Access to Antiviral Medications and Information in an Influenza Pandemic

Public Engagement on Facilitating Access to Antiviral Medications and Information in an Influenza Pandemic
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 56
Release: 2012-08-20
Genre: Medical
ISBN: 0309256941

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Influenza pandemics overwhelm health care systems with thousands or hundreds of thousands of sick patients, as well as those worried they may be sick. In order to ensure a successful response to the patient swell caused by a pandemic, robust planning is essential to prepare for challenges public health officials may face. This includes the need to quickly distribute and dispense antiviral medications that can reduce the severity and duration of disease to large numbers of people. In response to a request from the Centers for Disease Control, the Institute of Medicine's Forum on Medical and Public Health Preparedness for Catastrophic Events held a series of workshops that explored the public's perception of how to facilitate access to antiviral medications and treatment during an influenza pandemic. To help inform potential strategies still in the development stages at the CDC, workshops were held in Fort Benton, Montana; Chattanooga, Tennessee; and Los Angeles, California during February and March 2012 to consider the usefulness of several alternative strategies of delivering antiviral medication to the public. Participants considered how the normal systems for prescribing and dispensing antiviral medications could be adjusted to ensure that the public has quick, safe, and equitable access to both potentially life-saving drugs and information about the pandemic and treatment options. This document summarizes the workshops.

Combating the Threat of Pandemic Influenza

Combating the Threat of Pandemic Influenza
Author: Paul F. Torrence
Publisher: John Wiley & Sons
Total Pages: 308
Release: 2007-09-28
Genre: Medical
ISBN: 0470179708

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Drug discovery for influenza antivirals Priorities for combating pandemic influenza include rapid detection and identification, the quick administration of available drugs to treat the infection, the development of new antivirals, and the development of vaccines. Since lead-time may be required to produce an effective vaccine, antivirals would serve as a key first line of defense in containing an outbreak. Diverse antivirals, acting through different mechanisms, would help stay the development of resistant viruses. Thus, drug discovery for influenza antivirals is an important public health–related endeavor. With chapters contributed by leading international specialists, this guide gets readers up to speed on the latest advances and technologies in diverse approaches to drug discovery, covering: Existing antivirals, including broadly effective anti-respiratory virus agents The development of high-throughput screening assays IFN resistance The development of nucleic acid–based antiviral drugs Antiviral RNAi strategies targeting influenza virus Other promising antiviral drug discovery strategies Combating the Threat of Pandemic Influenza: Drug Discovery Approaches consolidates the latest information on diverse approaches into one comprehensive resource. It is an invaluable, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health.

Pandemic Influenza Preparedness and Response

Pandemic Influenza Preparedness and Response
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 62
Release: 2009
Genre: Medical
ISBN: 9241547685

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This guidance is an update of WHO global influenza preparedness plan: the role of WHO and recommendations for national measures before and during pandemics, published March 2005 (WHO/CDS/CSR/GIP/2005.5).

National Strategy for Pandemic Influenza

National Strategy for Pandemic Influenza
Author:
Publisher:
Total Pages: 24
Release: 2005
Genre: Emergency management
ISBN:

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"Once again, nature has presented us with a daunting challenge: the possibility of an influenza pandemic. Scientists and doctors cannot tell us where or when the next pandemic will strike, or how severe it will be, but most agree: at some point, we are likely to face another pandemic. And the scientific community is increasingly concerned by a new influenza virus known as H5N1 -- or avian flu -- that is now spreading through bird populations across Asia, and has recently reached Europe. While avian flu has not yet acquired the ability to spread easily from human to human, there is still cause for vigilance. The virus has developed some characteristics needed to cause a pandemic: It has demonstrated the ability to infect human beings, and it has produced a fatal illness in humans. If the virus were to develop the capacity for sustained human-to-human transmission, it could spread quickly across the globe. Our country has been given fair warning of this danger to our homeland -- and time to prepare. My administration has developed a comprehensive national strategy, with concrete measures we can take to prepare for an influenza pandemic. Our strategy is designed to meet three critical goals: First, we must detect outbreaks that occur anywhere in the world; second, we must protect the American people by stockpiling vaccines and antiviral drugs, and improve our ability to rapidly produce new vaccines against a pandemic strain; and, third, we must be ready to respond at the federal, state and local levels in the event that a pandemic reaches our shores."--President George Bush.

The Threat of Pandemic Influenza

The Threat of Pandemic Influenza
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 431
Release: 2005-04-09
Genre: Medical
ISBN: 0309095042

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Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.

Influenza pandemic

Influenza pandemic
Author: United States. Government Accountability Office
Publisher:
Total Pages:
Release: 2008
Genre: Antiviral agents
ISBN:

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